肿瘤预防与治疗2019，Vol.32Issue(7)：580-587,8.
喉鳞状细胞癌及癌前病变 R0 切除术后复发危险因素研究
Risk Factors for Laryngeal Squamous Carcinoma and Recurrence after R0 Resection of Precancerous Lesions
摘要
Abstract
Objective: To investigate the factors for recurrence of laryngeal carcinoma, 95 cases of laryngeal carcinoma and precancerous lesions were retrospectively reviewed according to protein expression of carcinoma markers (including p53, c-Myc, PTEN, survivin, p21 and p27 proteins) and clinicopathologic factors. Methods: Ninety-five patients with laryngeal carcinoma and vocal cord squamous epithelial precancerous lesions were collected in Cancer Hospital Chinese Academy of Medical Sciences from January 1999 to December 2015. Three years after R0 resection, recurrence occurred in 41 of the 95 patients. Immunohistochemical methods were used to detect the expression of p53, c-Myc, PTEN, survivin, p21 and p27. Results: There was significant difference between the recurrence group and the nonrecurrence group in the expression of c-Myc, survivin and PTEN (P<0. 05); there was no significant difference in the expression of p21, p27 and p53 ( P>0. 05). Recurrence of laryngeal carcinoma after operation was correlated to pathological differentiation of tumor, and was not statistically related to age, gender and alcohol consumption and smoking. The worse the differentiation of tumor was, the higher the recurrence rate was. Conclusion: Factors for recurrence of laryngeal carcinoma are complex. The expression of c-Myc, survivin and PTEN is related to postoperative recurrence of laryngeal cancer, which may be used as an indicator of postoperative recurrence of laryngeal cancer.关键词
喉癌/p53/c-Myc/PTEN/survivin/p21/p27Key words
Laryngeal carcinoma/p53/c-Myc/PTEN/Survivin/p21/p27分类
医药卫生引用本文复制引用
鲁海珍,尹英爱,吕宁..喉鳞状细胞癌及癌前病变 R0 切除术后复发危险因素研究[J].肿瘤预防与治疗,2019,32(7):580-587,8.基金项目
首都卫生发展科研专项项目(编号:首发2014-2-2053) This study was supported by Special Project of Capital Health Research and Development ( NO. 2014－2－2053) . （编号:首发2014-2-2053）
