肿瘤预防与治疗2019，Vol.32Issue(7)：607-611,5.
25例喉神经内分泌癌的诊治与临床分析
Diagnosis, Treatment and Clinical Analysis of 25 Cases of Laryngeal Neu-roendocrine Carcinoma
摘要
Abstract
Objective: To investigate the clinical features, pathological manifestations, treatment methods, prognosis of laryngeal neuroendocrine carcinoma, and compare laser therapy under laryngoscope and open operations. Methods: From June 1995 to September 2018, 25 cases of neuroendocrine carcinoma originating from larynx confirmed by pathology in o-tolaryngology, head and neck surgery of Beijing Tongren Hos-pital were reviewed. Results: Of 25 cases of laryngeal neuro-endocrine carcinoma, 4 were typical carcinoid, 13 were atypi-cal carcinoid, 6 were small cell neuroendocrine tumors, 1 was large cell neuroendocrine tumor, and 1 was complex neuroendocrine carcinoma ( small cell neuroendocrine carcinoma and moderately differentiated squamous cell carcinoma). Fifteen patients took CO2 laser surgery under self-retaining laryngo-scope, among which 1 of them received CO2 laryngectomy plus neck lymph node dissection under self-retaining laryngo-scope, 7 patients received partial laryngectomy, and 3 received total laryngectomy plus radiotherapy and chemotherapy after operation. The follow-up period was 3-102 months, with a median follow-up period of 26 months. The overall 3-year and 5-year survival rates of 25 patients were 64% and 48% , respectively. There was no significant difference between the 5-year survival rates of early stage (T1,T2) patients with open laryngeal surgery (66. 7% ) and those of patients with open surgery (50. 0% ) (P>0. 05). Conclusion: Laryngeal neuroendocrine tumors often occur in the supraglottic epiglottis. There is no necrosis on the surface of broad-based rough tumors under laryngeal scope. The final diagnosis depends on comprehensive pathological and immunohistochemical staining after operation. CO2 laser treatment of early neuroendocrine cancer can a-chieve the same therapeutic effect as open surgery, and improve the life quality of patients.关键词
喉癌/神经内分泌肿瘤/类癌Key words
Laryngeal carcinoma/Neuroendocrine tumor/Carcinoid分类
医药卫生引用本文复制引用
张洋,段翰源,李祖飞,郭伟,尹高菲,黄俊伟,陈晓红,黄志刚,钟琦..25例喉神经内分泌癌的诊治与临床分析[J].肿瘤预防与治疗,2019,32(7):607-611,5.基金项目
国家自然科学基金(编号:XMLX201507) （编号:XMLX201507）
首都卫生发展专项(编号:首发-2018-1-2052) （编号:首发-2018-1-2052）
北京市卫生系统高层次人才培养计划(编号:2015-3-022) This study was supported by National Science Foundation of China ( NO. XMLX201507) , Health Devel-opment Special Project of Capital ( NO. 2018-1-2052) and Training Project for High Level Talents from Beijing Health System (NO. 2015-3-022). （编号:2015-3-022）
