肿瘤预防与治疗2019，Vol.32Issue(7)：612-617,6.
涎腺分泌性癌7例临床病理分析
Mammary Analogue Secretory Carcinoma of Salivary Gland: Clinicopath-ological Features of 7 Cases
摘要
Abstract
Objective: To investigate the clinicopathologic features, diagnostic criteria and differential diagnosis of mammary analogue secretory carcinoma ( MASC). Methods:Seven case of MASC were collected from our hospital from Jan-uary 2011 to October 2018. Clinical data and pathological fea- tures of 7 cases of MASC were evaluated respectively. Microscopic examination and immunohistochemical study were per-formed with literature review. Results: The 7 patients comprised 5 men and 2 women, with a median and mean age of 44 and 45. 1 years (21－63), respectively. All of the patients were treated with a slowly growing painless mass as the fist symptom, six occurred in the parotid and one in the submandibular gland. All of the tumors were solitary masses, and the mean diame-ter of the tumors was 2. 77 cm (1. 3－3. 5 cm). Two neoplasms are well circumscribed, and the rest always invade the sali-vary glands; microscopic features showed multilobulated mass, subdivided into smaller segments by fibrous septa. These cells are arranged into microcystic, cribriform, tubular, papillary, follicular (thyroid like), or solid nests. Tumor cells have uniform round and vesicular nuclei with central nucleoli and eosinophilic pink vacuolated cytoplasm. The immunohistochemi-cal features of 7 cases were positive for CK7, Vimetin, Mammaglobin and S-100, and negative for P63, DOG1 and CD117, Ki-67 positive rate ranged from 2% to 15% . Follow-up data were available for 4 patients, and follow-up period ranged from 8 to 43 months. The 4 patients remained well without recurrence. Conclusion: MASC is a rare low-grade malignant tumor of salivary glands, which was classified recently. The histopathologic, immunohistochemical, cytogenetic and molecular genetic features of MASC are helpful to distinct it with acinic cell cancinoma.关键词
涎腺肿瘤/分泌性癌/临床病理特征/鉴别诊断Key words
Salivary gland neoplasms/Mammary analogue secretory carcinoma/Clinicopathological features/Differential diagnosis分类
医药卫生引用本文复制引用
杨雯,贺晓燕,陈方园,高露,蔡梅,窦朝念,张菊,杨勇,徐澍..涎腺分泌性癌7例临床病理分析[J].肿瘤预防与治疗,2019,32(7):612-617,6.基金项目
贵州省科学技术基金基础项目(编号:黔科合LG字[2012]068号) This study was supported by Basic Project of Guizhou Science and Technology Fund [ NO. LG ( 2012 ) 068] . （编号:黔科合LG字[2012]068号）
