实验动物与比较医学Issue(6)：48-53,6.DOI:10.3969/j.issn.1674-5817.2018.01.009
长爪沙鼠近交系培育中血液生理生化指标的变化
Dynamic Changes of Biochemical and Physiological Indices in Ischemia-prone Inbred Gerbil Strain during Breeding
摘要
Abstract
Objective To investigate a dynamic curve of blood biochemical and physiological characteristics in the process of inbreeding ischemia-prone gerbil, and to provide basic data for inbred animal breeding. Methods The 17 blood biochemical and 22 physiological indices of blood samples from inbred 11 th to 20 th generation (F11 to F20) were detectioned by Beckman automatic biochemical analyzer (CX5) and Japanese photoelectric automatic blood cell analyzer (MEK-7222K) . Results The results showed that the uricacidcrystal (URIC), lactate dehydrogenase (LD), creatine kinase (CK), alanine aminotransferase (ALT), high density lipoproteins (HDLD), magnesium (MG), red blood cell (RBC), leukocyte (WBC), eosinophil (EOS), neutrophil count (NEUT), monocytes (MON), basophilic granulocyte (BAS), blood platelet (PLT), thrombocytocrit (PCT), platelet distribution width (PDW), hemoglobin (HGB), mean corpuscular hemoglobin (MCH), and red blood cell distribution width (RDW) of F11-20 gerbil were increasing. The lymphocyte (LYM), creatinine (CRE), blood urea nitrogen (BUN), alkaline phosphatase (ALP), glucose (GLU) showed a decreasing trend. The hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), average platelet volume (MPV) value was stable. The majority of indicators tend to be stable after F17. Conclusion The gerbil inbred strain has a certain influence on the most of the blood physiological and biochemical indices.关键词
长爪沙鼠/近交系/脑缺血模型/血液生化指标/血液生理指标Key words
Gerbil/Inbred/Ischemia model/Biochemical characteristics/Physiological index分类
生物科学引用本文复制引用
李迎,王冬平,陈振文,杜小燕,崔晓霞,马兰芝,尚世臣,何晓亚,黄斌,赵权,李桂军..长爪沙鼠近交系培育中血液生理生化指标的变化[J].实验动物与比较医学,2018,(6):48-53,6.基金项目
国家科技支撑计划课题(2015BAI09B01-04) （2015BAI09B01-04）
