实验动物与比较医学Issue(6)：57-59,3.DOI:10.3969/j.issn.1674-5817.2018.01.011
CMU/1和CMU/2长爪沙鼠与F344大鼠及BALB/c小鼠4项凝血指标分析
Comparison of Four Blood Coagulation Factors among Gerbil CMU/1, Gerbil CMU/2 and F344 Rat and BALB/c Mouse
摘要
Abstract
Objective To detect and compare the differences of coagulation factors between inbred gerbil CMU/1 and CMU/2, inbred rat F344, and inbred mouse BALB/c; then to analyze the characteristics of inbred ischemia-prone gerbil. Methods The four channel blood coagulation analyzer was used to determine three kinds of inbred animals' plasma prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), and thrombin time (TT) . The SPSS23.0 software was applied for statistical analysis of data. Results The APTT FIB of CMU/1 and the FIB of CMU/2 of ischemia-prone gerbil displayed high standard deviation. The PT and FIB of CMU/1 and CMU/2 showed significantly different compared with that of F344 rat. The APTT of both ischemia-prone inbred gerbil lines demonstrated significant difference compared with BALB/c mouse and F344 rat. Conclusion The 4 coagulation factors of ischemia-prone inbred gerbil lines are consistent with those of inbred BALB/c mouse; which are significantly different from those of inbred F344 rat.关键词
脑缺血模型/长爪沙鼠/近交系/凝血因子/F344大鼠/BALB/c小鼠Key words
Ischemia model/Gerbil/Inbred lines/Coagulation factors/F344 rat/BALB/c mouse分类
生物科学引用本文复制引用
李迎,陈振文,杜小燕,崔晓霞,马兰芝,尚世臣,赵志兵,赵权,李桂军,王冬平..CMU/1和CMU/2长爪沙鼠与F344大鼠及BALB/c小鼠4项凝血指标分析[J].实验动物与比较医学,2018,(6):57-59,3.基金项目
国家科技支撑计划课题(2015BAI09B01-04) （2015BAI09B01-04）
