中国组织工程研究2019，Vol.23Issue(33)：5378-5384,7.DOI:10.3969/j.issn.2095-4344.1817
干细胞治疗阿尔茨海默病的研究现状及发展趋势
Stem cell therapy for Alzheimer’s disease: research status and developmental trend
摘要
Abstract
BACKGROUND: Alzheimer's disease is a degenerative brain disease, and there are no known drugs for curing Alzheimer's disease. Stem cell transplantation provides a new therapeutic method for Alzheimer's disease. OBJECTIVE: To reveal the theme, evolutionary path and research progress of stem cell therapy for Alzheimer's disease, in a bid to provide reference for the research and clinical treatment of Alzheimer's disease. METHODS: A computer search of CNKI, CBM, ISI Web of knowledge, and Embace was performed with the keywords of "Alzheimer's disease" and "stem cells" + "Alzheimer's disease," in Chinese and English, respectively We conducted a visualized knowledge mapping and literature review of stem cell therapy for Alzheimer's disease using CiteSpace software. RESULTS AND CONCLUSION: The evolutionary path of research on stem cell therapy for Alzheimer's disease is closely related to stem cell transplantation research. The main line of this research is single and prominent, which is developed and implemented based on the keywords of "Alzheimer's disease - stem cells, neural stem cells - transplantation - bone marrow mesenchymal stem cells, mesenchymal stem cells, human umbilical cord mesenchymal stem cells, beta-amyloid - tissue engineering," and the core domains composed by these Human stem cell clinical trials are ongoing in the early stage. The safety, efficacy and ethical issues of stem cells should be emphasized. The regulation of stem cell differentiation should become an issue of concern, and individualized stem cell treatment should be implemented as soon as possible.关键词
阿尔茨海默病/神经干细胞/骨髓间充质干细胞/脐带间充质干细胞/CiteSpace/国家自然科学基金Key words
Alzheimer's disease/ neural stem cells/ bone marrow mesenchymal stem cells/ umbilical cord mesenchymal stem cells/ CiteSpace/ National Natural Science Foundation of China分类
医药卫生引用本文复制引用
许革新,张云霞,张海英..干细胞治疗阿尔茨海默病的研究现状及发展趋势[J].中国组织工程研究,2019,23(33):5378-5384,7.基金项目
海南省科技财政计划资助[海南省自然科学基金面上项目(818MS063)]，项目参与人：许革新；国家自然科学基金项目(81660224)，项目负责人：张海英；国家自然科学基金项目(31760310)，项目负责人：张云霞；大学生创新创业训练计划项目(HYCX2018032，201811810032)，项目参与人：许革新 （818MS063）
