中国临床药理学与治疗学Issue(7)：814-819,6.DOI:10.12092/j.issn.1009-2501.2018.07.015
达格列净对2型糖尿病患者动脉内膜中层厚度的影响
Effects of dapagliflozin on intima-medial thickness of carotid artery in type 2 diabetic mellitus patients
摘要
Abstract
AIM:To assess the effects of dapagliflozin on intima-medial thickness (IMT) of carotid artery in type 2 diabetic mellitus patients.METHODS:A total of 113 patients of type 2 diabetic mellitus were divided into dapagliflozin group (58 cases) and control group (55 cases).All patients were recruited in this randomized trial.Based on the intervention of life style, all patients undertook oral aspirin 0.1 g/d and atorvastatin 20 mg/d.The dapagliflozin group was given dapagliflozin 10 mg every day, while the control group was given other oral antidiabetic drug with/without insulin therapy.Course of treatment was 24 weeks.The various biochemical indices and carotid artery IMT were detected and the data were analyzed and compared between the two groups.RESULTS:In the dapagliflozin group, the IMT decreased after dapagliflozin therapy (P ＜0.01).In the control group, the distinction of IMT had not statistical significant between before and after therapy (P＞ 0.05).There were significant differences in carotid artery IMT between the two groups after therapy (P ＜ 0.01), while there was no statistically significant difference between decreased blood sugar and blood pressure level (P＞ 0.05).CONCLUSION:Dapagliflozin can decrease the IMT in patients with type 2 diabetic mellitus, which is closely related to cardiovascular benefit in patients with type 2 diabetic mellitus.关键词
达格列净/动脉内膜中层厚度/2型糖尿病Key words
dapagliflozin/intima-media thickness/type 2 diabetes mellitus分类
医药卫生引用本文复制引用
叶盛开,张碧莹,温洁,刘卫平,任霞,陈海英,杜颖,李雪,张茹,于莉..达格列净对2型糖尿病患者动脉内膜中层厚度的影响[J].中国临床药理学与治疗学,2018,(7):814-819,6.基金项目
中华社会救助基金会安心必达2型糖尿病公益项目(AXBD-Z-0001) （AXBD-Z-0001）
