中国临床药理学与治疗学Issue(7)：825-829,5.DOI:10.12092/j.issn.1009-2501.2018.07.017
特异性操控神经元活性法研究全麻药作用机制的进展
Advances in research on the mechanism of general anesthesia by specific manipulation of neuron activities
摘要
Abstract
Manipulation of the neuron activity is an important method in the research of general anesthetics.Traditional methods mainly involve electrical stimulation and local administrations of drugs into brain nuclei/lesion of nuclei, etc.have many shortcomings such as extended targets, poor spatial and time accuracy, and non-specific cell types.In recent years, novel strategies such as optogenetics and chemogenetics for controlling the activities of specific neurons were established, which are of high precisions on time and space scales, and of great significance to explore the retailed mechanisms of general anesthetics.This review summarized the principles and progresses of optogenetics and chemogenetics in the mechanism research of general anesthetics.关键词
光遗传学/药理遗传学/全身麻醉/睡眠-觉醒调节/特异性神经元操控Key words
optogenetics/chemogenetics/general anesthesia/sleep-wake regulation/manipulation of specific neurons分类
医药卫生引用本文复制引用
徐薇,曲卫敏,洪宗元..特异性操控神经元活性法研究全麻药作用机制的进展[J].中国临床药理学与治疗学,2018,(7):825-829,5.基金项目
国家自然科学基金面上项目(81671318,81171255) （81671318,81171255）
安徽省科技攻关项目(1501041157) （1501041157）
