中国临床药理学与治疗学Issue(7)：830-835,6.DOI:10.12092/j.issn.1009-2501.2018.07.018
纳米载体特异性靶向TAMs治疗肿瘤的研究进展
Recent advances of nanocarriers targeting tumor-associated macrophages in tumor therapy
摘要
Abstract
It is well known that tumor-associated macrophages (TAMs) play a vital role in the occurrence, development and metastasis of many tumors.Increasing evidences show that TAMs may be a promising target for tumor therapy and play an important role in future targeted treatment.Therefore, the design of TAMs-targeting nanocarriers which are able to achieve appropriate intratumoral biodistribution so as to effectively inhibit the growth of tumor has become a hot spot in recent years.In this review, the advantages of nanocarriers targeting TAMs are described.Since TAMs display a number of upregulated surface proteins (mannose receptor, folate receptor, cluster of differentiation 163, cluster of differentiation 11 b, etc.), specific targeting using targeting ligands coupled to nanocarriers are discussed in the review, which may improve the ability of anti-tumor drug targeting TAMs.关键词
肿瘤相关巨噬细胞/纳米载体/靶向修饰/肿瘤治疗Key words
tumor-associated macrophages/nanocarriers/targeted modification/tumor therapy分类
医药卫生引用本文复制引用
赵小彬,余陈欢,夏爱晓,俞文英,俞冰..纳米载体特异性靶向TAMs治疗肿瘤的研究进展[J].中国临床药理学与治疗学,2018,(7):830-835,6.基金项目
浙江省"实验动物基因工程学"创新学科建设(201604) （201604）
台州市科技计划项目(1702KY08) （1702KY08）
浙江省科技计划项目(2015C33185) （2015C33185）
