中国神经再生研究（英文版）2019，Vol.14Issue(12)：2029-2034,6.DOI:10.4103/1673-5374.262570
Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor
Ignacio Jure 1Alejandro F. De Nicola 1Florencia Labombarda2
作者信息
- 1. Laboratorio de Bioquímica Neuroendocrina, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina
- 2. Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
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摘要
Abstract
A new role has emerged for progesterone after discovering its potent actions away from reproduction in both the central and the peripheral nervous system. The aim of the present report is to discuss progester-one’s mechanisms of action involved in myelination, remyelination and neuroinflammation. The pivotal role of the classic progesterone receptor is described and evidence is compiled about progesterone’s direct effects on oligodendrocyte linage and its indirect effects on oligodendrocyte precursor cell differentiation by decreasing the neuroinflammatory environment.关键词
progesterone/progesterone receptor/oligodendrocyte differentiation/myelination/remyelination/neuroinfammationKey words
progesterone/progesterone receptor/oligodendrocyte differentiation/myelination/remyelination/neuroinfammation引用本文复制引用
Ignacio Jure,Alejandro F. De Nicola,Florencia Labombarda..Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor[J].中国神经再生研究（英文版）,2019,14(12):2029-2034,6.
