首页|期刊导航|中国神经再生研究（英文版）|Physiological and pathological effects of amyloid-β species in neural stem cell biology
中国神经再生研究（英文版）2019，Vol.14Issue(12)：2035-2042,8.DOI:10.4103/1673-5374.262571
Physiological and pathological effects of amyloid-β species in neural stem cell biology
摘要
Abstract
Although amyloid-β peptide is considered neurotoxic, it may mediate several physiological processes during embryonic development and in the adult brain. The pathological function of amyloid-β peptide has been ex-tensively studied due to its implication in Alzheimer’s disease, but its physiological function remains poorly understood. Amyloid-β peptide can be detected in non-aggregated (monomeric) and aggregated (oligomeric and fibrillary) forms. Each form has different cytotoxic and/or physiological properties, so amyloid-β pep-tide and its role in Alzheimer’s disease need to be studied further. Neural stem cells and neural precursor cells are good tools for the study on neurodegenerative diseases and can provide future therapeutic applica-tions in diseases such as Alzheimer’s disease. In this review, we provide an outline of the effects of amyloid-β peptide, in monomeric and aggregated forms, on the biology of neural stem cells/neural precursor cells, and discuss the controversies. We also describe the possible molecular targets that could be implicated in these effects, especially GSK3β. A better understanding of amyloid-β peptide (both physiological and pathologi-cal), and the signaling pathways involved are essential to advance the field of Alzheimer’s disease.关键词
amyloid-β peptide/Aβ/neural stem cells/neural progenitor cells/Alzheimer’s disease/amyloid precursor protein/toxicity/neurogenesis/gliogenesis/GSK3βKey words
amyloid-β peptide/Aβ/neural stem cells/neural progenitor cells/Alzheimer’s disease/amyloid precursor protein/toxicity/neurogenesis/gliogenesis/GSK3β引用本文复制引用
Adela Bernabeu-Zornoza,Raquel Coronel,Charlotte Palmer,María Monteagudo,Alberto Zambrano,Isabel Liste..Physiological and pathological effects of amyloid-β species in neural stem cell biology[J].中国神经再生研究（英文版）,2019,14(12):2035-2042,8.基金项目
This work was supported by grants from the MICINN-ISCIII (PI-10/00291 and MPY1412/09), MINECO (SAF2015-71140-R) and Comunidad de Madrid (NEUROSTEMCM consortium （PI-10/00291 and MPY1412/09）
S2010/BMD-2336) (all to IL). Financial support: This work was supported by grants from the MI-CINN-ISCIII (PI-10/00291 and MPY1412/09), MINECO (SAF2015-71140-R) and Comunidad de Madrid (NEUROSTEMCM consortium （all to IL）
S2010/BMD-2336) (all to IL). （all to IL）
