中国神经再生研究（英文版）2019，Vol.14Issue(12)：2192-2198,7.DOI:10.4103/1673-5374.262598
CNB-001 reduces paraplegia in rabbits following spinal cord ischemia
Paul A. Lapchak 1Paul D. Boitano 2Rene Bombien 2Daisy Chou 2Margot Knight 2Anja Muehle 2Mihaela Te Winkel 2Ali Khoynezhad2
作者信息
- 1. Neurocore LLC, Pomona, CA, USA
- 2. Department of Surgery, Memorial Care Health System, Long Beach, CA, USA
- 折叠
摘要
Abstract
Spinal cord ischemia associated with trauma and surgical procedures including thoraco-abdominal aortic aneurysm repair and thoracic endovascular aortic repair results in devastating clinical deficits in patients. Because spinal cord ischemia is inadequately treated, we studied the effects of [4-((1E)-2-(5-(4-hydroxy-3-methoxystyryl-)-1-phenyl-1H-pyrazoyl-3-yl) vinyl)-2-methoxy-phenol)] (CNB-001), a novel curcumin-based compound, in a rabbit SCI model. CNB-001 is known to inhibit human 5-lipoxy-genase and 15-lipoxygenase and reduce the ischemia-induced inflammatory response. Moreover, CNB-001 can reduce the level of oxidative stress markers and potentiate brain-derived neurotrophic factor and brain-derived neurotrophic factor receptor signaling. The Tarlov scale and quantal analysis technique results revealed that CNB-001 administered as an intravenous dose (bolus) 30 minutes prior to spinal cord ischemia improved the behaviors of female New Zealand White rabbits. The improvements were similar to those produced by the uncompetitive N-methyl-D-aspartate receptor antagonist memantine. At 48 hours after aortic occlusion, there was a 42.7% increase (P < 0.05) in tolerated ischemia duration (n = 14) for rabbits treated with CNB-001 (n = 16), and a 72.3% increase for rabbits treated with the positive control memantine (P < 0.05) (n = 23) compared to vehicle-treated ischemic rabbits (n = 22). CNB-001 is a poten-tial important novel treatment for spinal cord ischemia induced by aortic occlusion. All experiments were approved by the CSMC Institutional Animal Care and Use Committee (IACUC #4311) on November 1, 2012.关键词
curcumin analog/spinal cord injury/spinal cord ischemia/thoraco-abdominal aortic aneurysm/thoracic endovascular aortic repair/motor function/neuroprotection/neurorepairKey words
curcumin analog/spinal cord injury/spinal cord ischemia/thoraco-abdominal aortic aneurysm/thoracic endovascular aortic repair/motor function/neuroprotection/neurorepair引用本文复制引用
Paul A. Lapchak,Paul D. Boitano,Rene Bombien,Daisy Chou,Margot Knight,Anja Muehle,Mihaela Te Winkel,Ali Khoynezhad..CNB-001 reduces paraplegia in rabbits following spinal cord ischemia[J].中国神经再生研究（英文版）,2019,14(12):2192-2198,7.
