中国中医药信息杂志2018，Vol.25Issue(9)：66-70,5.DOI:10.3969/j.issn.1005-5304.2018.09.016
中心组合设计-响应面法优化复方当归补血汤提取工艺
Optimization of Extraction Technology of Compound Danggui Buxue Decoction by Central Composite Design-Response Surface Method
摘要
Abstract
Objective To optimize extraction technology of Compound Danggui Buxue Decoction. Methods On the basis of single factor test, factorial design, and fastest rise test, yield and weight sum of extraction efficiency of ferulic acid, paeoniflorin and ligustilide were set as response, and central composite design-response surface method was used to optimize the extraction technology of Danggui Buxue Decoction. Results The optimum conditions consisted of ultrasonic-wave extraction for 60 min, ethyl alcohol concentration 36％ and the ratio of material to solvent = 1:94. Conclusion This method has high extraction efficiency, easy operation and good predictability.关键词
复方当归补血汤/析因设计/中心复合设计-响应面法/提取工艺Key words
Compound Danggui Buxue Decoction/factorial design/central composite design-response surface method/extraction technology分类
医药卫生引用本文复制引用
马肖,金永新,陈煜娟,要林青,张瑞堂,夏鹏飞,张红梅..中心组合设计-响应面法优化复方当归补血汤提取工艺[J].中国中医药信息杂志,2018,25(9):66-70,5.基金项目
西北民族大学科研项目(31920160115) （31920160115）
甘肃中医学院中青年科研基金(ZQ2014-2) （ZQ2014-2）
甘肃省中药药理与毒理学重点实验室自主基金项目(ZDSYS-KJ-2016-008) （ZDSYS-KJ-2016-008）
