中国中医药信息杂志2018，Vol.25Issue(9)：71-75,5.DOI:10.3969/j.issn.1005-5304.2018.09.017
多指标正交试验优化芪蛭益肺颗粒水提醇沉工艺
Optimization of Water Extraction and Alcohol Precipitation Process of Qizhi Yifei Granules by Multi-Index Orthogonal Experimental
摘要
Abstract
Objective To optimize the extraction and alcohol precipitation process of Qizhi Yifei Granules by multi index orthogonal experiment. Methods With extraction rate of astragaloside in Astragali Radix, quercetin-3-O-β-D-glucose-7-O-β-D-gentian diglucoside in Descurainiae Semen Lepidii Semen and yield rate of dry extract as indexes, the extraction process of Qizhi Yifei Granules was optimized. Taking the retention rate of astragaloside and quercetin-3-O-β-D-glucose-7-O-β-D-gentian diglucoside as indexes, the alcohol precipitation process was optimized. Results The best water extraction process was as follows: adding 10 times amount of water, extracting for 1.5 h, 3 times. The optimum alcohol precipitation process was: concentrated to the relative density of 1.05–1.10 (60 ℃), adding ethanol to 60％ and alcohol precipitation. Conclusion The optimized extraction and alcohol precipitation process is stable and feasible, which can provide the basis for the preparation.关键词
芪蛭益肺颗粒/水提醇沉/黄芪甲苷/槲皮素-3-O-β-D-葡萄糖-7-O-β-D-龙胆双糖苷Key words
Qizhi Yifei Granules/water extraction and alcohol precipitation/astragaloside/quercetin-3-O-β-D-glucose-7-O-β-D-gentian diglucoside分类
医药卫生引用本文复制引用
王文平,倪健,冷新,杨春静,游龙泰,刘艺,塞那,梁潇,尹兴斌..多指标正交试验优化芪蛭益肺颗粒水提醇沉工艺[J].中国中医药信息杂志,2018,25(9):71-75,5.基金项目
北京市科技计划"十病十药"研发(Z020071620099) （Z020071620099）
