郑国将 1毛相濡 2丁刚玉 2王星 1徐建华 2靳令经 1聂志余2
作者信息
- 1. 201000 上海上海健康医学院附属嘉定区中心医院神经内科
- 2. 同济大学附属同济医院神经内科
- 折叠
摘要
Abstract
Objective To investigate the predictive value of ASPECTS, DRAGON and SEDAN scores for hemorrhagic transformation after intravenous thrombolysis in patients with acute ischemic stroke (AIS). Methods The baseline data of consecutive AIS patients treated with intravenous thrombolysis from Department of Neurology of Tongji Hospital of Tongji University from December 2012 to December 2017 were retrospectively collected, and all patients were scored with ASPECTS, DRAGON and SEDAN scales. The primary endpoint was hemorrhagic transformation during hospitalization. The receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive value of the three scales, and the area under the ROC curve was expressed by C value; the goodness of fit of the three scales were judged by Hosmer-Lemeshow (H-L) goodness-of-fit test; and the correlation between the three scales and outcome events was evaluated by logistic regression analysis. Results A total of 199 patients were included in this study. The C value of ASPECTS, DRAGON and SEDAN scores in all patients were 0.889, 0.810 and 0.793, respectively; in anterior circulation were 0.889, 0.823 and 0.788, respectively; in male patients were 0.893, 0.788 and 0.818, respectively; in female patients were 0.882, 0.808 and 0.720, respectively (all P<0.05). The χ2 value of H-L goodness-of-fit test of the three scales in all patients were 8.253, 2.685 and 7.511, respectively; in anterior circulation were 9.875, 4.330 and 6.441, respectively; in male patients were 8.966, 1.697 and 3.049, respectively; in female patients were 4.284, 6.548 and 7.669, respectively (P<0.05 were only for ASPECTS in anterior circulation and male groups, and all the rest P>0.05). The OR in logistic regression analysis of the three scales in all patients were 0.588, 1.839 and 2.229, respectively; in anterior circulation were 0.567, 1.951, 2.198, respectively; in male patients were 0.595, 1.969 and 2.675, respectively; in female patients were 0.573, 1.833 and 1.787, respectively (all P<0.05). Conclusions ASPECTS, DRAGON and SEDAN scales all have strong predictive ability for the risk of hemorrhagic transformation after intravenous thrombolysis in AIS patients, and ASPECTS is superior to the other two prediction models.关键词
缺血性卒中/静脉溶栓/出血转化/预测模型Key words
Ischemic stroke/Intravenous thrombolysis/Hemorrhagic transformation/Prediction model
