郑国将 1卓子良 2于婷 2刘渊华 2徐建华 2李云霞 1聂志余2
作者信息
- 1. 201000 上海上海健康医学院附属嘉定区中心医院神经内科
- 2. 同济大学附属同济医院神经内科
- 折叠
摘要
Abstract
Objective To investigate the predictive value of ASPECTS, DRAGON and THRIVE scores on the adverse prognosis at 3 months after intravenous thrombolysis in patients with acute ischemic stroke (AIS). Methods Clinical data of consecutive 214 AIS patients treated with intravenous thrombolysis from Department of Neurology of Tongji Hospital of Tongji University from December 2012 to December 2017 were retrospectively collected. All the patients were scored with ASPECTS, DRAGON and THRIVE scales. The primary endpoint was the prognosis at 3 months after symptoms onset, and the poor prognosis was defined as mRS ≥3. The predictive value of the three scales were compared by the area under the receive operating characteristic (ROC) curve (C value). The goodness of fit of the three scales were judged by Hosmer-Lemeshow (H-L) goodness-of-fit test. The correlation between actual and predictive outcome was evaluated by Spearman correlation analysis. Results 207 patients were enrolled in the final analysis, of which 58 (28%) patients had poor prognosis. The C value of ASPECTS, DRAGON and THRIVE scales in all patients were 0.825, 0.800 and 0.765, respectively; in anterior circulation were 0.850, 0.817 and 0.797, respectively;in man patients were 0.764, 0.736 and 0.697, respectively; in female patients were 0.909, 0.878 and 0.861 (all P﹤0.05). The χ2 value of H-L goodness-of-fit test of the three scales in all patients were 4.865, 6.758 and 7.836, respectively; in anterior circulation were 3.932, 6.060 and 4.328, respectively; in man patients were 7.021, 6.631 and 4.647, respectively; in female patients were 2.493, 2.972 and 10.788, respectively (all P>0.05). Spearman correlation coefficient (r) of the three scales in all patients were -0.532, 0.473 and 0.418, respectively; in anterior circulation were -0.572, 0.501 and 0.471, respectively; in man patients were -0.427, 0.359 and 0.300, respectively; in female patients were -0.688, 0.626 and 0.601, respectively (all P﹤0.05). Conclusions ASPECTS, DRAGON and THRIVE all can predict the risk of 3-month poor prognosis after intravenous thrombolysis in AIS patients, of which ASPECTS is superior to the other two predictive models.关键词
缺血性卒中/静脉溶栓/预后/预测模型/受试者工作特征曲线Key words
Ischemic stroke/Intravenous thrombolysis/Prognosis/Predictive model/Receiver operating characteristic curve
