中国卒中杂志2019，Vol.14Issue(6)：549-554,6.DOI:10.3969/j.issn.1673-5765.2019.06.006
体检人群新发脑出血相关危险因素分析—— 一项来自社区的观察性研究
Analysis of Clinical Characteristics and Risk Factors of New-onset Intracranial Hemorrhage:a Large Prospective Community-based Study
摘要
Abstract
Objective To investigate the clinical characteristics and risk factors for new-onset intracranial hemorrhage (ICH) among physical examination population in Northern China. Methods Basic data of physical examination people in Kailuan community from June 2006 to October 2007 were collected by questionnaires, physical examination and laboratory examination. A face-to-face follow-up for all subjects were taken every 24 months, until the end of 2015. The new-onset stroke during the whole follow-up were recorded. Comparing the relevant data between the new-onset ICH group and the control group, cox regressive analysis was used to assess the relevant factors of new-onset hemorrhagic stroke. Results A total of 94 993 participants without a history of stroke completed the follow-up and were included in the final analysis. Stroke occurred in 3568 (3.8%) participants during the follow-up, including 746 (0.8%) ones with intracranial hemorrhage. There were significant difference in the percentage of male, old age, low income, low level of education, high BMI, and history of hypertension, diabetes, hyperlipidemia, atrial fibrillation between the hemorrhage group and the control group, and all the above rates were higher in the ICH group (P<0.05). After adjusting for the confounding factors, high systolic blood pressure ( HR 1.026, 95% CI 1.018-1.035, P<0.0001), high diastolic blood pressure ( HR 1.040, 95% CI 1.026-1.055, P<0.0001) and high glucose ( HR 1.127, 95% CI 1.046-1.215, P=0.0017) were all the independent risk factors of intracranial hemorrhage. Conclusions Male, old age, low income, low level of education, high BMI and hyperlipidemia, hypertension, diabetes were related with the risk of ICH, of which hypertension and high glucose were the independent risk factors of ICH.关键词
脑出血/危险因素/血压/血糖/血脂Key words
Intracranial hemorrhage/Risk factor/Blood pressure/Glucose/Lipid引用本文复制引用
王丹丹,王安心,张倩,张怡君,赵性泉..体检人群新发脑出血相关危险因素分析—— 一项来自社区的观察性研究[J].中国卒中杂志,2019,14(6):549-554,6.基金项目
脑出血损伤机制与干预评价研究(2018YFC1312200)北京市医院管理局"登峰"人才培养计划(DFL20150501)神经系统重大疾病创新药物临床评价技术平台建设(2017ZX09304018) （2018YFC1312200）
