中国卒中杂志2019，Vol.14Issue(6)：568-572,5.DOI:10.3969/j.issn.1673-5765.2019.06.009
脑梗死患者同型半胱氨酸与颈动脉内膜中层厚度的关系研究
Relationship between Plasm Homocysteine Level and Carotid Intima-media Thickness in Cerebral Infarction Patients
钟旗 1蓝香琳 2唐革秀 2李维平 3潘鹏克 2韦仕荣2
作者信息
- 1. 518035 深圳深圳市第二人民医院神经内科
- 2. 河池市人民医院神经内科
- 3. 深圳市第二人民医院神经外科
- 折叠
摘要
Abstract
Objective To investigate the correlation between carotid intima-media thickness (cIMT) and plasma Hcy concentration in patients with acute cerebral infarction. Methods Clinical data of consecutive patients with acute cerebral infarction from Department of Neurology, Guangxi Hechi People's Hospital from January 2017 to December 2018 were collected. cIMT was measured using Doppler ultrasound. According to whether the cIMT ≥1 mm or not, these patients were divided into cIMT thickening group and cIMT no-thickening group. Plasma Hcy concentration in all patients were measured. Multivariate logistic regression analysis was used to investigate the correlation between cIMT and plasma Hcy level. Results A total of 226 patients were enrolled in this study, with 34 patients in cIMT no-thickening group and 192 patients in cIMT thickening group. The median plasma Hcy level in cIMT non-thickening group was 11.2 μmol/L, and that in cIMT thickening group was 13.0 μmol/L, with statistically significant difference (P=0.012). In addition, age (69.1±9.7 years vs 58.2±1.2 years, P<0.001), pulse pressure (64.0±17.4 mm Hg vs 53.6±13.6 mm Hg, P<0.001), hs-CRP [3.78 (1.5-10.6) mg/L vs 1.5 (0.9-4.2) mg/L, P=0.010)] in cIMT thickening group were all significantly higher than that in cIMT no-thickening group. After adjusting for age, pulse pressure, and hs-CRP level, the logistic regression analysis showed that plasma Hcy level was an independent risk factor of cIMT. For every 10 μmol/L increase in plasma Hcy level, cIMT increased by 0.037 mm (95% CI 0.0075-0.068, P=0.002). Conclusions Plasma Hcy level was an independent risk factor of cIMT in patients with acute cerebral infarction.关键词
脑梗死/颈动脉内膜中层/同型半胱氨酸Key words
Cerebral Infarction/Carotid Intima-media/Homocysteine引用本文复制引用
钟旗,蓝香琳,唐革秀,李维平,潘鹏克,韦仕荣..脑梗死患者同型半胱氨酸与颈动脉内膜中层厚度的关系研究[J].中国卒中杂志,2019,14(6):568-572,5.
