中国卒中杂志2019，Vol.14Issue(6)：612-618,7.DOI:10.3969/j.issn.1673-5765.2019.06.018
蛛网膜下腔出血病理生理机制研究进展
Advance in Pathophysiological Mechanism of Subarachnoid Hemorrhage
摘要
Abstract
Subarachnoid hemorrhage (SAH) is a common cerebrovascular disease, with a high rate of mortality and disability. Despite many advances in drugs and endovascular treatment, the improvement of clinical prognosis in patients with SAH still faces many challenges. Research has shown that some pathophysiological reaction after SAH can influence the clinical prognosis, these pathophysiological mechanisms includ cerebral vascular spasm, oxidative stress, inflammation, impairment of blood-brain-barrier, brain edema, apoptosis, pyroptosis, necrocytosis and autophagy, cortical spreading depression and microthrombosis and etc. This paper reviewed the recent advance in pathophysiology mechanism in SAH, to provide reference for SAH treatment and drugs research& development.关键词
蛛网膜下腔出血/临床转归/病理生理Key words
Subarachnoid hemorrhage/Clinical prognosis/Pathophysiology引用本文复制引用
张昌林,倪小佳,林浩,吴俊标,李春花,黎劭学,蔡业峰..蛛网膜下腔出血病理生理机制研究进展[J].中国卒中杂志,2019,14(6):612-618,7.基金项目
2016年度广东省中医药局课题(20161097)广州市科技计划项目(201604020003)广州中医药大学2017年高水平大学建设(A1-AFD018171Z11096)广东省中医院院内专项(YN2015BZ05) （20161097）
