中国卒中杂志2019，Vol.14Issue(6)：619-624,6.DOI:10.3969/j.issn.1673-5765.2019.06.019
微粒体在缺血性卒中的作用
The Role of Microparticles in Ischemic Stroke
摘要
Abstract
When there appears vascular endothelial dysfunction, acute and chronic vascular inflammation and hypercoagulation, microparticles (MPs) can be released by platelets, white blood cells and endothelial cells. The roles of different kinds of MPs in the pathological process of ischemic stroke are different: the level of leukocyte-derived MPs (LMPs) is elevated in patients with ischemic stroke, the high level of LMPs can aggravate the injury of vascular endothelial cells and the high level of platelet-derived MPs in plasma for a long time can induce microvascular thrombosis. In addition, different kinds of MPs can reflect the degree of vascular endothelial injury, induce and aggravate endothelial dysfunction. At the same time, mRNA and microribonucleic acid carried in MPs can promote the proliferation of endothelial cells, promote neovascularization in atherosclerotic plaques, and make plaques more prone to rupture and bleeding.关键词
微粒体/缺血性卒中/内皮细胞/血栓形成Key words
Microparticle/Ischemic stroke/Endothelial cell/Thrombosis引用本文复制引用
周蕾,吴冬雨,姚小梅,时彦莹,朱宪策,黄晶,王春雪,张宁..微粒体在缺血性卒中的作用[J].中国卒中杂志,2019,14(6):619-624,6.基金项目
国家重点研发计划National Key Research &Development Program of China(2016YFC1307200)北京市科委脑计划(Z161100000216131) 215北京市卫生系统高层次卫生技术人才项目(2015-3-038) （2016YFC1307200）
