浙江医学2018，Vol.40Issue(16)：1799-1802,4.DOI:10.12056/j.issn.1006-2785.2018.40.16.2017-2336
血浆标志物对急性心肌梗死患者住院期间并发谵妄的预测价值分析
Plasma biomarkers for predicting occurrence of delirium in patients with acute myocardial infarction during hospitalization
摘要
Abstract
Objective To assess the predictive value of plasma cardiac troponinⅠ (cTn I), copeptin, arginine vasopressin (AVP), atrial natriuretic peptide(ANP), N- terminal fragment of pro- brain natriuretic peptide (NT- proBNP), brain natriuretic peptide (BNP) and adrenomedullin (ADM) levels for occurrence of delirium secondary to acute myocardial infarction during hospital stay. Methods Three hundred and twenty patients with acute myocardial infarction and 160 healthy subjects (controls) were enrolled in the study. Enzyme- linked immune sorbent assay was used to determine plasma concentrations of biomarkers. The value of biomarkers in predicting occurrence of in- hospital delirium was analyzed with receiver operating characteristic (ROC) curve. Results Plasma concentrations of these biomarkers were significantly higher in the acute myocardial infarction patients than those in the controls (all P＜0.01). In- hospital delirium developed in 50 patients (15.6％). Patients with delirium had significantly higher plasma concentrations of these biomarkers than those without delirium (all P ＜0.01). The predictive ability of copeptin and NT- proBNP was significantly higher than that of cTnⅠ(both P＜0.05); while there were no significant differences in predictive ability between cTn I and other biomarkers (all P＞0.05). Combination of copeptin with NT pro- BNP significantly increased the predictive performance compared to two biomarkers alone (both P＜0.05). Conclusion Plasma concentrations of copeptin and NT- proBNP possess high predictive value for occurrence of in- hospital delirium in patients with acute myocardial infarction, and combined detection of these two biomarkers may further increase the predictive performance.关键词
和肽素/氨基末端脑钠肽原/急性心肌梗死/谵妄Key words
Copeptin/N- terminal fragment of pro- brain natriuretic peptide/Acute myocardial infarction/Delirium引用本文复制引用
汤蓓,钟泽,沈红卫,相鹏,方中华,胡佳元,吴金平,余平安..血浆标志物对急性心肌梗死患者住院期间并发谵妄的预测价值分析[J].浙江医学,2018,40(16):1799-1802,4.基金项目
杭州市科技发展计划项目(20150633B83) （20150633B83）
