浙江医学2018，Vol.40Issue(16)：1803-1806,1813,5.DOI:10.12056/j.issn.1006-2785.2018.40.16.2018-95
肝硬化患者血型和病情分级与VWF、F Ⅷ和ADAMTS13因子的关系
Association of ABO blood types with VWF, FⅧ and ADAMTS13 levels and disease severity in liver cirrhosis patients
潘优敏 1郭仁勇 2陈瑜2
作者信息
- 1. 310003 杭州,浙江大学医学院附属第一医院输血科
- 2. 310003 杭州,浙江大学医学院附属第一医院检验科
- 折叠
摘要
Abstract
Objective To investigate the association of ABO blood types with VWF, FⅧ and ADAMTS13 levels and disease severity in liver cirrhosis (LC) patients. Methods Two hundred and twenty eight patients with liver cirrhosis and 168 healthy controls were enrolled in the study. Plasma VWF:Ag and ADAMTS13:Ag levels were assessed by ELISA; Fibrinogen, D- dimmer and F VIII:Ac were measured by an automated coagulometric method; ALT, AST, TB were measured by an automated biochemical analyzer; PLT were measured by blood analyzer, and blood ABO phenotyping was performed by the indirect technique. Results Increased VWF:Ag, F VIII:Ac and decreased ADAMTS13:Ag were observed in LC patients compared with healthy controls (all P＜0.01). Moreover, higher VWF:Ag and F VIII:Ac (both P＜0.05) were observed in non- O LC patients, and significant results remained when patients were stratified according to CTP and MELD score (P＜0.05). However, no difference was observed in ADAMTS13:Ag between LC patients with O and non- O blood types (P＞0.05). Conclusion LC patients with non- O blood type have increased VWF: Ag and F VIII: Ac, which may lead to dysfunction of microcirculation, and are likely to have more severe conditions.关键词
肝硬化/ABO血型/血管性血友病因子/Ⅷ因子/血管性血友病因子裂解蛋白酶Key words
Liver cirrhosis/ABO blood groups/Von Willebrand factor/Factor Ⅷ/ADAMTS13引用本文复制引用
潘优敏,郭仁勇,陈瑜..肝硬化患者血型和病情分级与VWF、F Ⅷ和ADAMTS13因子的关系[J].浙江医学,2018,40(16):1803-1806,1813,5.
