浙江医学2018，Vol.40Issue(16)：1807-1810,4.DOI:10.12056/j.issn.1006-2785.2018.40.16.2017-2748
自噬相关蛋白Beclin1、LC3- Ⅱ、Atg5在前列腺腺癌组织中的表达及意义
Expression of Beclin1, LC3- Ⅱ and Atg5 in prostate adenocarcinoma and its significance
王钱虎1
作者信息
- 1. 310006 杭州市第一人民医院中心实验室
- 折叠
摘要
Abstract
Objective To investigate the expression of Beclin1, LC3- Ⅱ and Atg5 in prostate adenocarcinoma (PCa) and its clinical significance. Methods The expression of Beclin1, LC3- Ⅱ and Atg5 was detected in 60 PCa tissue samples by immunohistochemical method, and the relationship between their expression levels and the clinical features of PCa patients was analyzed. Results The expressions of Beclin1 and LC3- Ⅱin PCa tissue was significantly lower and the expression Atg5 was significantly higher than those in benign prostate hyperplasia (BPH) tissue (P＜0.05). There was a significant correlation between Belin1 and LC3- Ⅱ. The expression of Beclin1 and LC3- Ⅱwas associated with Gleason score, serum PSA level, lymph node metastasis and bone metastasis (P＜0.05), but was not associated with age of patients (P ＞0.05); but no such association was observed for the expression of Atg5. Conclusion The abnormal expressions of autophagy- related proteins Beclin1, LC3- Ⅱ, Atg5 are observed in PCa, which may be involved in the occurrence and development of PCa.关键词
前列腺腺癌/自噬/Beclin1/LC3-Ⅱ/Atg5Key words
Prostatic adenocarcinoma/Autophagy/Beclin1/LC3- Ⅱ/Atg5引用本文复制引用
王钱虎..自噬相关蛋白Beclin1、LC3- Ⅱ、Atg5在前列腺腺癌组织中的表达及意义[J].浙江医学,2018,40(16):1807-1810,4.
