浙江医学2018，Vol.40Issue(16)：1811-1813,3.DOI:10.12056/j.issn.1006-2785.2018.40.16.2017-2314
不同孕期血浆纤维蛋白原和纤维蛋白单体的变化及意义
Dynamic changes of plasma fibrinogen and fibrin monomer during pregnancy and their clinical implication
摘要
Abstract
Objective To investigate the dynamic changes of plasma fibrinogen(FIB) and fibrin monomer(FM) during the normal gestation period and their clinical implication. Methods Plasma fibrinogen, monomer and D- dimer concentrations were measured with Clauss assay and immunoturbidimetry respectively in 124 normal pregnant women at first trimester(12～15 weeks), second trimester(22～25 weeks) and third trimester(35～40 weeks); and 100 non- pregnant women (controls). Plasma prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) were also analyzed. Results Compared with non- pregnant group, plasma levels of FIB, FM and D- dimer were significantly higher in pregnant women at the first trimester. During the third trimester, PT, APTT and TT were significantly decreased (P＜0.01). There were significant differences in plasma FMand D- dimer levels in pregnant women at different gestation periods(P＜0.01). Conclusion The plasma levels of FIB, FMand D- dimer in normal pregnant women are dynamically changed, which may be used to predict the coagulation status during the gestation period.关键词
妊娠/纤维蛋白原/纤维蛋白单体/D-二聚体Key words
Gestation/Fibrinogen/Fibrin monomer/D- dimer引用本文复制引用
黄国永,王海虹,郑加永,汪海,潘豪杰,董叶..不同孕期血浆纤维蛋白原和纤维蛋白单体的变化及意义[J].浙江医学,2018,40(16):1811-1813,3.基金项目
温州市医药卫生科研项目(2016A06) （2016A06）
