浙江医学2018，Vol.40Issue(16)：1819-1822,4.DOI:10.12056/j.issn.1006-2785.2018.40.16.2018-1332
不同剂量右美托咪定联合罗哌卡因腹横肌平面阻滞用于腹腔镜卵巢切除术后镇痛的效果
Analgesic efficacy of different dose dexmedetomidine with ropivacaine for transverses abdominis plane block in patients undergoing laparoscopic ovariectomy
摘要
Abstract
Objective To investigate the postoperative analgesic efficacy of different dose dexmedetomidine (Dex) combined with ropivacaine for ultrasound- guided transverses abdominis plane (TAP) block in patients undergoing laparoscopic ovariectomy (LO). Methods One hundred and eighty patients undergoing elective LO were administrated ultrasound- guided bilateral TAP block after surgery. According to the different formulations of local anesthetics, patients were randomly divided into four groups with 45 cases in each: group Con with 0.375％ ropivacaine+saline, group Dex 0.5 with 0.375％ ropivacaine+ 0.5μg/kgDex, group Dex 1.0 with 0.375％ ropivacaine + 1.0μg/kgDex, and group Dex1.5 with 0.375％ ropivacaine + 1.5μg/kgDex. The volume of the above local anesthetics for TAP were all 20mL for each side. Besides, patient- controlled intravenous oxycodone analgesia pump was provided to all patients. With the goal of visual analogue scale (VAS) ≤3 in postoperation, oxycodone consumption, Ramsay sedation score and postoperative complications were evaluated and recorded at 4, 6, 8, 12, 24, and 48h after operation. Results Compared with group Con and group Dex0.5, the accumulated oxycodone consumption in group Dex1.0 and group Dex1.5 was significantly reduced at 24h and 48h after surgery (P＜0.05). There was no significant difference among these four groups in Ramsay sedation score at all the time- points (P＞0.05). Moreover, compared with group Con and group Dex1.0, the incidence of xerostomia in group Dex1.5 was more commonly occurred(P＜0.05). Conclusion While the doses of dexmedetomidine at 1.0μg/kg and 1.5μg/kg with ropivacaine for TAP block could significantly enhanced the postoperative analgesic efficacy in patients undergoing laparoscopic ovariectomy, and 1μg/kgdose may cause fewer postoperative adverse reactions.关键词
右美托咪定/罗哌卡因/腹横肌平面阻滞/腹腔镜卵巢切除术Key words
Dexmedetomidine/Ropivacaine/Transverses abdominis plane/Laparoscopic ovariectomy引用本文复制引用
陈宏博,吴艳琴,金资源,李军..不同剂量右美托咪定联合罗哌卡因腹横肌平面阻滞用于腹腔镜卵巢切除术后镇痛的效果[J].浙江医学,2018,40(16):1819-1822,4.基金项目
浙江省医药卫生科技计划项目(2017KY147) （2017KY147）
