肿瘤防治研究2018，Vol.45Issue(3)：175-178,4.DOI:10.3971/j.issn.1000-8578.2018.17.0970
肿瘤干细胞蛋白质组学研究方法的新进展
New Advances in Proteomics Research Methods of Cancer Stem Cells
李明1
作者信息
- 1. 中南大学湘雅医学院医学检验系临床生化教研室 410013 长沙
- 折叠
摘要
Abstract
Proteomics is an emerging discipline to apply multiple technical approaches for studying the proteomics. It has an ability to identify various kinds of signal transduction complexes and paths in stem cell differentiation. First, various approaches can be taken for obtaining sufficient tumor stem cells required for proteomic analysis; second, it is possible to make use of subcellular isolation technique as a tool of proteomic analysis; moreover, proteomic method can be used for identifying tumor stem cell nonspecific proteins; finally, proteomic method is employed for searching new therapeutic targets. The new stem cell culture technique and the latest-level mass spectrometry enable the research on cancer stem cells to step into a new stage, therefore, the application of proteomics can effectively expound which paths have gotten involved in regulation of cancer stem cell activation and other molecular processes, further identify and search single molecules as biomarkers or therapeutic targets.关键词
肿瘤干细胞/蛋白质组学/亚细胞分离/治疗靶Key words
Cancer stem cells/Proteomics/Subcellular isolation/Treatment target分类
医药卫生引用本文复制引用
李明..肿瘤干细胞蛋白质组学研究方法的新进展[J].肿瘤防治研究,2018,45(3):175-178,4.
