肿瘤药学2019，Vol.9Issue(3)：407-410,4.DOI:10.3969/j.issn.2095-1264.2019.03.11
肿瘤显像药物18F-FLT的制备及其在早期肺癌与炎症鉴别中的应用研究
The Synthesis of 18F-FLT and its Application in the Differential Diagnosis of Early Lung Cancer and Inflammation
陈小娟 1周明 2李程3
作者信息
- 1. 湖南省肿瘤医院药学部,湖南 长沙,410013
- 2. 中南大学湘雅医院PET中心,湖南 长沙,410008
- 3. 湖南师范大学医学院,湖南 长沙,410013
- 折叠
摘要
Abstract
Objective It's difficult to differentiate early lung cancer and inflammation in clinical practice but 18F-FDG cannot meet the clinical needs now. This study intends to synthesize 18F-FLT, a tumor proliferation imaging drug, to research its potential in differentiating early lung cancer and inflammation. Methods In this study, (5'-O-DMTr-2'-deoxy-3'-O-nosyl-β-D-threo-pentofuranosyl)-3-N-BOC-thymine was used as the precursor, and 18F-FLT was synthesized automatically by Tracerlab FXN Pro synthesis module. After quality control was carried out, 5 early lung cancer patients were screened out for 18F-FLT and 18F-FDG PET imaging contrast. Results The radiochemical yield of 18F-FLT was (12.2±1.5, n=5) %, and the radiochemical purity was more than 99%. Comparing the 18F-FLT and 18F-FDG PET images, the imaging results of 3 patients were coincident but different of 2 patients. Moreover, pathology results confirmed that 18F-FLT was sensitive to early lung cancer, but not sensitive to inflammation. Conclusion 18F-FLT was synthesized successfully. It has the potential of distinguishing early lung cancer from inflammation.关键词
3’-脱氧-3’-18F-氟代胸腺嘧啶核苷/早期肺癌/炎症/合成Key words
18F-FLT/Early lung cancer/Inflammation/Synthesis分类
医药卫生引用本文复制引用
陈小娟,周明,李程..肿瘤显像药物18F-FLT的制备及其在早期肺癌与炎症鉴别中的应用研究[J].肿瘤药学,2019,9(3):407-410,4.
