摘要
Abstract
Objective To investigate analgesic effects of olanzapine combined with oxycodone hydrochloride on patients with advanced hepatocellular carcinoma, and to analyze the changes of pain stress and psychological states. Methods Eighty-four patients with pain in advanced hepatocellular carcinoma were divided into routine group and combined group by a random number table. They were all given mFOLFOX6 chemotherapy. The routine group was treated with oxycodone hydrochloride, while the combined group was treated with olan-zapine combined with oxycodone hydrochloride. The changes of pain numeric rating scale (NRS) scores were compared before treatment, after 3d, 1 week and 2 weeks of treatment. The changes of pain degrees, serum pain stress related index levels and psychological states be-fore and after treatment, average times of pain-outbreaks, average sleeping time and safety during treatment were compared between the two groups. Results There were significant differences in NRS scores between moments, groups and interaction (P<0.05). After treatment, the NRS scores showed a time-dependence in both groups (P<0.05), and they were lower in the combined group than in the routine group after 1 week and 2 weeks of treatment (P<0.05). The serum levels of 5-HT, NPY and PGE2 in the two groups were all decreased after treatment (P<0.05), and they were lower in the combined group than in the routine group (P<0.05). After treatment, the scores of anxiety and depres-sion were decreased in both groups (P<0.05), and the scores in the combined group were lower than in the routine group (P<0.05). The average times of pain-outbreaks in the combined group was significantly less than in the routine group (P<0.05). In addition, patients in the combined group had averagely longer sleep time than those in the routine group (P<0.05). The incidence of adverse reactions in the com-bined group was similar to that in the routine group, without statistically significant difference (P>0.05). Conclusion Olanzapine combined with oxycodone hydrochloride has a good analgesic effect on patients with pain in advanced hepatocellular carcinoma. It can improve the serum indexes related to pain stress and psychological state, reduce the outbreaks of pain and prolong sleeping time, yet without significant increase of adverse reactions.关键词
奥氮平/盐酸羟考酮/肝癌/癌性疼痛/止痛作用/疼痛应激Key words
Olanzapine/Oxycodone hydrochloride/Liver cancer/Cancer pain/Analgesic effect分类
医药卫生
