阿衣夏木古丽·艾则孜 1马丽丽 1柳江 1韩忠成1
作者信息
- 1. 新疆维吾尔自治区人民医院肿瘤科,新疆 乌鲁木齐,830001
- 折叠
摘要
Abstract
Objective To investigate the influence of modified Fuzheng Yiliu decoction combined with chemotherapy on the curative efficiency and serum TGF-β, IL-1A and PSA levels of prostate cancer patients and their correlation. Methods Seventy-two patients with prostate cancer were randomly divided into observation group (n=36) and control group (n=36). Patients in control group got gemcitabine plus cisplatin chemotherapy. The observation group was treated with Fuzheng Yiliu Decoction combined with gemcitabine and cisplatin. The effective rates of the two groups were evaluated and compared. The serum TGF-β, IL-1A and PSA levels and cellular immunity were detected before treatment and after 1 course and 2 courses treatment. The relationships of the above indicators in the observation group with the curative effect were analyzed. Results The effective rate of observation group was 86.11% (31/36), which was higher than the 63.89% (23/36) of the control group (P<0.05). After one course of treatment and two courses of treatment, the CD3+ and CD4+ levels and CD4+/CD8+of the observation group increased as compared with before treatment, and were higher than those of the control group (P<0.05). Yet the se-rum TGF-β, IL-1A and PSA levels and CD8+ of the observation group decreased, and were lower than those of the control group (P<0.05). In the control group, the CD3 +, CD4 + levels and CD4+/CD8+ increased, while serum TGF-β, IL-1A and PSA levels and CD8+ decreased after two courses of treatment, as compared with before treatment (P<0.05). Pearson linear correlation analysis showed that the serum levels of TGF-β, IL-1A and PSA in observation group were negatively correlated with CD3+ and CD4+ levels and CD4+/CD8+, but positively corre-lated with CD8+ level (P<0.05). In addition, in the observation group, the levels of CD3+ and CD4+ and CD4+/CD8+ before and after treatment of the patients with ineffective treatment were lower than those of patients who got curative effects, however, their serum TGF-β, IL-1A and PSA levels and CD8+ were higher those of the patients who got curative effects (P<0.05). Spearman correlation analysis showed that serum TGF-β, IL-1A and PSA levels in observation group were negatively correlated with the curative effect (P<0.05). Conclusion Combination of chemotherapy with Fuzheng Yiliu decoction for prostate cancer can improve the curative effect and reduce the serum TGF-β, IL-1A and PSA levels. The serum TGF-β, IL-1A and PSA levels are closely related to the immune function and curative effect.关键词
前列腺癌/扶正抑瘤汤/化疗/TGF-β/IL-1A/PSA/疗效/关系Key words
Prostate cancer/Fuzheng Yiliu decoction/Chemotherapy/TGF- beta/IL-1A/PSA/Curative effect/Relationship分类
医药卫生
