中国耳鼻咽喉头颈外科2018，Vol.25Issue(7)：358-362,5.DOI:10.16066/j.1672-7002.2018.07.004
主观性耳鸣患者静息态脑电地形图功率频谱研究
Estimation of spectral oscillatory power of resting-state EEG in subjective tinnitus
摘要
Abstract
OBJECTIVE To explor e the characteristics of spectral oscillatory power of resting-state electroencephalography(EEG) in subjective tinnitus patients and to lay the foundation for study of central mechanism of tinnitus.METHODS 31 subjects(15 subjects with subjective tinnitus and 16 age matching healthy subjects) underwent a 128-channel resting-state EEG analyses. After a series of preprocessing, data were segmented into 8 frequency bands, including δ(0.5～3.5 Hz), θ(4～7.5 Hz), α1(8～10 Hz), α2(10～12 Hz), β1(13～18 Hz), β2(18.5～21 Hz), β3(21.5～30 Hz) and γ(30.5～44 Hz). The group differences of spectral power were analyzed by independent t test. Correlation between spectral power of each frequency band and tinnitus subjective symptoms were also analyzed. RESULTS Significant higher spectral power of the α1, β and γ bandwere found in the left and right temporal areas of tinnitus group compared with that of normal group.Tinnitus subjects also had higher spectral powerof the δ and θ band in temporo-parietal areas than that of the normal group. There was no significant difference of spectral power in other frequency bands. Moreover, signif icant positive cor relation were found between tinnitus loudness and spectralpower of right anterior lateral(R=0.66, P =0.007) and right anterior medial(R=0.58, P =0.031) areas. CONCLUSION Tinnitus subjects have higher spectral oscillatory power on right and left temporal lobe and temporo-parietal area. A positive correlation exsit between tinnitus loudness andspectral power of right anterior lateral and medial areas in tinnitus subjects, whichindicate that central reorganizationexsit in tinnitus reorganization andγ band maybe considered as a possible biomarkerforthe tinnitus subjective symptom.关键词
耳鸣/脑电描记术/响度感觉/静息态/振荡功率频谱Key words
Tinnitus/Electroencephalography/Loudness Perception/resting state/spectral oscillatory power引用本文复制引用
蔡跃新,陈桂生,陈燕洪,郑亿庆,李佳鸿,杨海弟,陈玲,孙映凤,黄夏茵,熊浩,陈穗俊,陈宵铤..主观性耳鸣患者静息态脑电地形图功率频谱研究[J].中国耳鼻咽喉头颈外科,2018,25(7):358-362,5.基金项目
国家自然科学基金青年科学基金(81600808)、国家自然科学基金面上项目(81570935)、广东省自然科学基金(2016A030313318)、广东省自然科学基金博士启动项目(2015A030310134)和部属高校省级大学生创新创业训练计划项目(201601133)联合资助 （81600808）
