国际老年医学杂志2019，Vol.40Issue(4)：196-198,250,4.DOI:10.3969/j.issn.1674-7593.2019.04.002
新活素、左西孟旦对慢性心力衰竭急性加重期的治疗效果∗
Effects of Lyophilized Recombinant Human Brain Natriuretic Peptide and Levosimendan on Acute Exacerbation of Chronic Heart Failure
摘要
Abstract
Objective To explore the therapeutic effects of lyophilized recombinant human brain natriuretic peptide (Lr-BNP) and levosimendan in the treatment of acute exacerbation of chronic heart failure. Methods 47 patients with acute exacerbation of chronic heart failure between June 2015 and February 2016 were enrolled. They were randomly divided into Lr-BNP group and le-vosimendan group. Before and after treatment, serum levels of Galectin-3, pentraxin-3 (PTX-3) and B type natriuretic peptide (BNP), 18 meters walking time, clinical efficacy and rehospitalization rates after 3 months of follow-up were recorded. Results After treatment, the levels of Galectin-3, PTX-3 and BNP and the 18 meters walking time in the two groups were significantly lower than those before treatment (P<0.05). 18 meters walking time in the levosimendan group was significantly shorter than that in the Lr-BNP group ( P<0.05). The response rate in the levosimendan group was significantly higher than that in the Lr -BNP group (P<0.05). Conclusion Both Lr-BNP and levosimendan can improve the clinical symptoms and heart function in patients with a-cute exacerbation of chronic heart failure. The therapeutic effect of levosimendan is much better.关键词
慢性心力衰竭/新活素/左西孟旦/疗效Key words
Chronic heart failure/Lyophilized recombinant human brain natriuretic peptide/Levosimendan/Efficacy引用本文复制引用
张晔,汤燕,孙伟..新活素、左西孟旦对慢性心力衰竭急性加重期的治疗效果∗[J].国际老年医学杂志,2019,40(4):196-198,250,4.基金项目
江苏大学医学临床科技发展基金项目 (JLY20140094) 溧阳市重点研发计划 (社会发展) 项目 (LC2015009) （JLY20140094）
