国际老年医学杂志2019，Vol.40Issue(4)：225-228,238,5.DOI:10.3969/j.issn.1674-7593.2019.04.011
基于网络药理学研究淫羊藿-女贞子药对抗骨质疏松作用机制∗
Mechanism Analysis of Herba Epimedii/Fructus LigustriLucidi against Osteoprosis Using Network Pharmacology
摘要
Abstract
Objective To investigate the anti-osteoprosis mechanism of herba epimedii/fructus ligustri lucidi by using net-work pharmacology. Methods Traditional chinese medicine systems pharmacology (TCMSP) database was used to search for the ac-tive components of herba epimedii/fructus ligustri lucidi and to predict the target proteins and interaction proteins of active components. TCMSP database was combined with CTD and TTD database to obtain the core target proteins and the interaction proteins related to os-teoporosis. DAVID database was used to enrich the related signaling pathways of core target proteins. Results 249 chemical compo-nents and 19 active components were screened. The component target network and component target disease network were constructed by using Cytoscape. 53 core target proteins were screened and the core target protein ESR1 showed the highest degree value. 32 signa-ling pathways were obtained finally. Conclusion The therapeutic effect of herba epimedii/fructus ligustri lucidi on osteoprosis is reg-ulated by signaling pathways involved in the functions of osteoblast and osteoclast. ESR1 protein and its signaling pathways may play an important role.关键词
淫羊藿-女贞子药对/网络药理学/信号通路Key words
Herba epimedii/fructus ligustri lucidi/Network pharmacology/Signaling pathway引用本文复制引用
潘晓华,齐一璕,胡芳菲,刘戈,贾芙蓉,高雪..基于网络药理学研究淫羊藿-女贞子药对抗骨质疏松作用机制∗[J].国际老年医学杂志,2019,40(4):225-228,238,5.基金项目
吉林省科技厅重点科技攻关项目 (20150204070YY) 吉林省省级产业创新专项资金项目 (2017C059 -1) （20150204070YY）
