化工学报2019，Vol.70Issue(8)：3202-3209,8.DOI:10.11949/0438-1157.20190189
用微反应器实现可见光驱动的不对称氧化连续化反应
Asymmetric continuous oxidation in microreactor driven by visible light
摘要
Abstract
Photocatalysis, asymmetric synthesis and molecular oxygen oxidation are combined with continuous reaction. Using a glass microreactor, a continuous reaction for asymmetric α-hydroxylation of β-keto ester compound is oxidized by 1O2 under visible light. The reaction is catalyzed by cinchona alkaloid phase transfer catalyst in gas-liquid-liquid heterogeneous system. The desired product is obtained in high yield (95%) and good enantio selectivity (87.0%) in microreactor. Compared with the batch reaction, continuous reaction greatly reduces reaction residence time from 30 min to 1.08 min and maintains high stereo selectivity. The method has the advantages of fast, low energy consumption, continuous and high efficiency, and has good industrialization prospects.关键词
光化学/不对称有机催化/分子氧氧化/多相反应/分子合成/微反应器Key words
photochemistry/ asymmetric organic catalysis/ molecular oxygen oxidation/ heterogeneous reaction/molecular synthesis/ microreactor分类
化学化工引用本文复制引用
冯世豪,唐晓飞,都健,孟庆伟..用微反应器实现可见光驱动的不对称氧化连续化反应[J].化工学报,2019,70(8):3202-3209,8.基金项目
国家自然科学基金项目(21476041,U1608224,61633006) （21476041,U1608224,61633006）
