兽类学报2018，Vol.38Issue(2)：158-165,8.DOI:10.16829/j.slxb.150154
低温驯化对布氏田鼠小肠黏膜结构和黏膜免疫相关细胞的影响
Effects of cold acclimation on the structure of small intestinal mucosa and mucosal immunity-associated cells in Lasiopodomys brandtii
摘要
Abstract
Changes in environmental temperature affect the morphology and function of digestive tract in wild rodents. The small intestine is the main absorptive organ for nutrients, and its structure and function are plastic. To understand the response mechanisms of the structure and function of small intestinal mucosa to environmental temperature, we investigated the effects of cold acclimation on small intestinal mucosal structure and mucosal immunity-associated cells in Brandt's voles (Lasiopodomys brandtii) . We found that: (1) The villus length and the ratio of villus length to crypt depth (V/C) in the cold group were higher than that in the control group. (2) Cold acclimation increased the number of endothelial lymphocytes in the small intestine. (3) Cold acclimation significantly increased the number of goblet cells in the duodenum, the jejunum and the ileum. These results indicate that the structure of small intestinal mucosa and the number of immune cells may undergo plastic changes in cold environments. These changes may be related to high energy demand and changes of immune function.关键词
布氏田鼠/低温驯化/肠绒毛/黏膜免疫相关细胞Key words
Cold acclimation/Lasiopodomys brandtii/Mucosal immunity-associated cells/Small intestinal villi分类
生物科学引用本文复制引用
薄亭贝,张学英,王德华..低温驯化对布氏田鼠小肠黏膜结构和黏膜免疫相关细胞的影响[J].兽类学报,2018,38(2):158-165,8.基金项目
国家自然科学基金项目(31470474,31472006) （31470474,31472006）
北京市自然科学基金资助项目(5172024) （5172024）
