临床神经外科杂志Issue(2)：115-118,4.DOI:10.3969/j.issn.1672-7770.2019.02.005
垂体腺瘤手术治疗中对垂体功能保护的研究
Functional protection during operations of pituitary adenoma
摘要
Abstract
Objective To investigate the improvement of pituitary functions after operation , searching for risk factors of postsurgical hypopituitarism.Methods The clinical data of 138 patients with pituitary adenoma admitted to West China Hospital , Sichuan University from January 2016 to January 2017 were analyzed retrospectively.Results Of 138 patients, there were 70 males and 68 females with mean age of 50.Preoperative hypopituitarism were detected in 43 patients.Among them there were thyroid axis deficits (n＝13, 30.2%, 5 recovered after surgery ), male or female reproductive axis deficits (n＝15, 34.9%, 5 recovered after surgery ), adrenocorticotropic hormone (ACTH)／cortisol axis deficits ( n＝7, 16.3%, 1 recovered after surgery ), growth hormone (GH)／insulin-like growth factor-1 ( IGF-1) axis deficits ( n＝6, 14.0%, 3 recovered after surgery ) and total hypopituitarism ( n＝2, none recovered after surgery ).Postoperative newly endocrine deficit rates were 33.3%for thyroid axis (n＝2), 16.7% for male reproductive axis ( n＝1), 50% for adrenocorticotropic hormone (ACTH)／cortisol axis (n＝3) and zero for total hypopituitarism.Male patients were prone to have hypopituitarism (67%vs 43%, P＝0.008).Elder patients were prone to have hypopituitarism postoperative ( mean age 61.7 vs 47.9 years, P＝0.017).Conclusion The prognosis of hypopituitarism can be improved through operative resection of pituitary adenoma , especially in older patients or long-time suffering patients.关键词
垂体腺瘤/垂体功能低下/手术治疗/老年/内分泌轴受损Key words
pituitary adenoma/ hypopituitarism/ operative treatment / senium/ endocrine deficits分类
医药卫生引用本文复制引用
SONG Chen,ZHANG Nan-nanHU Yu..垂体腺瘤手术治疗中对垂体功能保护的研究[J].临床神经外科杂志,2019,(2):115-118,4.基金项目
国家自然科学基金面上项目(B177103136) （B177103136）
