临床神经外科杂志2019，Vol.16Issue(3)：185-189,5.DOI:10.3969/j.issn.1672-7770.2019.03.001
震颤起病与非震颤起病的帕金森病脑结构差异与脑深部电刺激的预后差异分析
Structural difference of tremor onset and non-tremor onset in Parkinson disease patients and prognosis of two groups
摘要
Abstract
Objective The deep brain stimulation( DBS) is the most useful surgical method in Parkinson disease ( PD), but different patients have discrepant prognosis.The tremor and non-tremor syndrome ( like rigidity, bradykinesia ) are the most common onset syndrome in PD. However, the prognosis of DBS and the brain grey matter difference have not been clarified. Methods 137 Parkinson patients from 2014 to 2018 were included in this research.70 patients were tremor onset(average age of 64, 20 males, 50 females, Hoehn-Yahr median score of 3).67 patients were non-tremor onset(average age of 60, 19 males, 48 females, Hoehn-Yahr median score of 3).The movement and non-movement scores as well as the structure image were collected.The voxel-based morphometry method was used to evaluate the structure image.Results No significant difference was found in age , gender, Hoehn-Yahr scale, UPDRSⅡ, UPDRSⅢ, HAMA, HAMD, MoCA score(all P＞0.05).The pre-operation scores and the post-stimulation score both showed the tremor onset patients had higher sub-score in tremor and the non-tremor onset patients have higher sub-score in rigidity(all P＜0.05).The VBM results showed the tremor onset patients have lower gray matter volume in posterior orbital cortex (FWE corrected, P＜0.05 ).Conclusions The post-operation prognosis is related to the onset syndrome.The posterior orbital cortex has lower gray matter volume in tremor onset patients , which might correlate with the tremor network.关键词
脑深部电刺激/帕金森病/基于体素的形态测量学Key words
deep brain stimulation/Parkinson disease/voxel-based morphometry study分类
医药卫生引用本文复制引用
ZHU Guan-yu,CHEN Ying-chuan,WANG Xiu..震颤起病与非震颤起病的帕金森病脑结构差异与脑深部电刺激的预后差异分析[J].临床神经外科杂志,2019,16(3):185-189,5.基金项目
国家自然科学基金(81671104,81830033,81701268,61761166004) （81671104,81830033,81701268,61761166004）
