临床神经外科杂志2019，Vol.16Issue(3)：208-212,5.DOI:10.3969/j.issn.1672-7770.2019.03.006
学历因素影响帕金森病脑深部电刺激术后焦虑和抑郁改善的研究
Discussion about the influence of education backgrounds on the improvement of anxiety and depression after DBS operation
摘要
Abstract
Objective To analyze the related factors which can affect the improvement of anxiety and depression symptoms after deep brain stimulation operation , including education level , amelioration about the rate of motor symptoms , etc.Methods This study included 90 patients with Parkinson’s disease(PD) undergoing STN-DBS.All patients were treated with unilateral or bilateral deep brain electrode implantation , and the stimulator was opened one month after operation.The patients were evaluated , including the basic information , levodopa equivalent daily dose ( LEDD), and scale assessment preoperatively , at 1 month follow-up and 3 months follow-up.The improvement of anxiety and depression symptoms were estimated according to the changes of the scores of Hamilton anxiety scale ( HAMA ) and Hamilton depression scale ( HAMD ).Then, correlation analysis were used to study the possible factors that could affect the improvement of anxiety and depression postoperatively.Results The symptoms of anxiety and depression were significant improved at 3 months follow-up ( all P＜0.05).Postoperative anxiety symptoms were significantly improved in the college-educated group(P＜0.05), and the similar improvement was also observed in the under college-educated group ( P ＜0.05 ).In the college-educated group, there was no significant difference between preoperative and postoperative HAMD scores , but the postoperative symptoms of depression improved significantly in the under college-educated group ( P ＜0.05 ). There was a positive correlation between the rate of anxiety improvement and the rate of movement improvement in the college-degree group ( P ＜0.05, r2 ＝0.35 ).A negative correlation trend between the rate of anxiety improvement and the rate of movement improvement were observed in the under college-degree group ( P ＝0.09, r2 ＝0.08 ).A positive correlation trend was observed between postoperative depression improvement rate and movement improvement rate in the college group( P＝0.26,r2 ＝0.11), and a negative correlation trend could be found between postoperative depression improvement rate and movement improvement rate in the college group ( P＝0.13,r2 ＝0.06).Conclusions The scores of HAMA and HAMD of the patients undergoing DBS operation are significantly decreased.In the college-degree group, there is a positive correlation trend between the improvement of anxiety and depression and the movement improvement rate.In the under college-degree group, there is a negative correlation trend between the improvement of anxiety and depression and the movement improvement rate.关键词
脑深部电刺激术/帕金森病/非运动症状/焦虑/抑郁Key words
deep brain stimulation/Parkinson’s disease/non-motor symptoms/anxiety/depression分类
医药卫生引用本文复制引用
SHI Lin,YUAN Tian-shuo,ZHU Guan-yu..学历因素影响帕金森病脑深部电刺激术后焦虑和抑郁改善的研究[J].临床神经外科杂志,2019,16(3):208-212,5.基金项目
国家自然科学基金(81701268) （81701268）
