临床神经外科杂志2019，Vol.16Issue(3)：213-218,6.DOI:10.3969/j.issn.1672-7770.2019.03.007
胚胎期可卡因暴露对子代大鼠海马CA1锥体神经元mEPSCs 的影响
Prenatal cocaine exposure alters mEPSCs of CA1 pyramidal neurons in the hippocampus of postnatal rats
摘要
Abstract
Objective To study the effect of the mechanism of prenatal cocaine exposure (PCE) to the spatial learning ability of the offspring.Methods Firstly, the effect of PCE on the ability of cocaine-induced conditioned place preference ( CPP) in offspring animals was studied. Then, the causes of spatial memory impairment in electrophysiology were studied , by use of whole-cell patch clamp technology , the changes of mini excitatory postsynaptic current ( mEPSC) in the dorsal and ventral hippocampus of the prenatal cocaine exposed rats were recorded .Results The results of CPP showed that PCE significantly prolonged the time of CPP formation in offspring rats , combined with the report that PCE damaged the spatial memory ability of the offspring , and then the effect of PCE on the CPP of the offspring was caused by the damage of spatial memory.It was shown that PCE inhibited the increase of mEPSC amplitude in dorsal hippocampal CA1 pyramidal neurons after acute cocaine exposure in offspring rats.Conclusion The result indicats that PCE causes functional damage to the dorsal hippocampal CA1 pyramidal neurons in the offspring , which can cause spatial memory to be affected.That can be the base of cocaine-induced CPP which is weakened by PCE.关键词
胚胎期可卡因暴露/条件位置偏爱/兴奋性突触后电流/背侧海马/腹侧海马Key words
prenatal cocaine exposure/conditioned place preference/excitatory postsynaptic current/dorsal hippocampus/ventral hippocampus分类
生物科学引用本文复制引用
FU Jian,QU Liang,WANG Xin..胚胎期可卡因暴露对子代大鼠海马CA1锥体神经元mEPSCs 的影响[J].临床神经外科杂志,2019,16(3):213-218,6.基金项目
国家自然科学基金(81671366) （81671366）
