临床神经外科杂志2019，Vol.16Issue(3)：266-269,4.DOI:10.3969/j.issn.1672-7770.2019.03.018
多途径联合用药治疗广泛耐药鲍曼不动杆菌颅内感染1例报告并文献复习
Multi-routes administration therapy for intracranial infection with extensively drug-resistant Acinetobacter baumannii( report of a case and review of literature)
摘要
Abstract
Objective To explore the treatment scheme for intracranial infection with extensively drug-resistant Acinetobacter baumannii and the technique for early diagnosis.Methods The clincal data of a case of intracranial infection with extensively drug-resistant Acinetobacter baumannii after craniotomy for craniocerebral trauma , the treatment scheme of extensively drug-resistant Acinetobacter baumannii intracranial infection was diacussed .Result During the hospitalization of the patient , the intracranial infection was confirmed by the next-generation sequencing (NGS) and procalcitonin ( PCT) testing in the CSF.The condition of infection was getting better after two weeks treatment by adjusting the scheme to tigecycline +polymyxin B intravenously and lumbar cistern drainage with gentamicin flushing, combined with intrathecal and intraventricular tigecycline +polymyxin B injection.Conclusion For the intracranial infection with extensively drug-resistant Acinetobacter baumannii , injecting tigecycline +polymyxin B intravenously and lumbar cistern drainage with gentamicin flushing , combined with intrathecal and intraventricular tigecycline +polymyxin B injection can be an effective therapeutic option.关键词
广泛耐药鲍曼不动杆菌/颅内感染/替加环素/多粘菌素B/降钙素原/鞘内注射Key words
extensively drug-resistant Acinetobacter baumannii/intracranial infection/tigecycline/polymyxin B/procalcitonin/intrathecalinjection分类
医药卫生引用本文复制引用
XIA Bo-ming,ZHU Lei,ZHANG Heng-zhu..多途径联合用药治疗广泛耐药鲍曼不动杆菌颅内感染1例报告并文献复习[J].临床神经外科杂志,2019,16(3):266-269,4.基金项目
扬州市重点研发项目(YZ2018088) （YZ2018088）
