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59例骶尾部脊索瘤术后放疗后的生存分析

Lu Shun Zou Bingwen Peng Xinhao Zhang Hanyi Lang Jinyi

肿瘤预防与治疗2019，Vol.32Issue(1)：38-42,5.
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肿瘤预防与治疗2019，Vol.32Issue(1)：38-42,5.DOI:10. 3969／j. issn. 1674-0904. 2019. 01. 006

59例骶尾部脊索瘤术后放疗后的生存分析

Survival Analysis of 59 Patients with Sacral Chordomas Treated by Surgery and Radiotherapy

Lu Shun 1Zou Bingwen 1Peng Xinhao 2Zhang Hanyi 3Lang Jinyi4

作者信息

  • 1. Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, Sichuan, China
  • 2. Department of Thoracic Cancer, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
  • 3. Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, Sichuan, China ( Lu Shun, Peng Xinhao, Zhang Hanyi, Lang Jinyi)
  • 4. Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, Sichuan, China
  • 折叠

摘要

Abstract

Objective: The aim of this study is to confirm whether patients with sacral chordoma benefit from adjuvant radio-therapy, and to determine the optimal photon radiotherapy module for patients with sacral chordomas after surgery. Methods: Fif-ty-nine patients pathologically diagnosed with non-metastatic sacral chordomas were recruited retrospectively for analysis. All patients received surgical resection after diagnosis. Among these patients, 22 were treated by gross total resection only, while 24 were treated with IG-IMRT after operation, 13 patients received GKS after operation. Results: The 5-year overall survival (OS) and recurrence-free survival (RFS) rates of all patients were 80. 1% and 44. 5% , respectively. For sacral chordoma patients treated exclusively by surgery, the 5-year OS and 5-year RFS rates were 90. 9% and 29. 8% , respectively. In strati- fied analysis, the 5-year OS rates were 87. 5% in the IG-IMRT group and 59. 3% in the GKS group, respectively; the 5-year RFS rates were 70. 9% and 35. 0% , respectively. Pa-tients with sacral chordomas treated with adjuvant radiotherapy had a better RFS than those treated by surgery only (P=0. 029). Moreover, compared with the GKS group, the IG-IMRT group exhibited better RFS (P=0. 023). Conclusion: We confirm that adjuvant radiotherapy improves RFS but not OS in sacral chordoma patients after surgery, and favorable RFS is observed following IG-IMRT. These results suggest that IG-IM-RT is an appropriate module of adjuvant radiotherapy for sacral chordoma patients.

关键词

骶尾部脊索瘤/外科手术/辅助放疗/IG-IMRT,GKS

Key words

Sacral chordoma/ Surgery/ Adjuvant radiotherapy/ Image-guided intensity modulated radiotherapy/ Gamma knife surgery

分类

医药卫生

引用本文复制引用

Lu Shun,Zou Bingwen,Peng Xinhao,Zhang Hanyi,Lang Jinyi..59例骶尾部脊索瘤术后放疗后的生存分析[J].肿瘤预防与治疗,2019,32(1):38-42,5.

基金项目

四川省科技厅课题(编号:2017HH0096) This study was supported by grants from Science and Technology Department of Sichuan Province ( NO. 2017HH0096) （编号:2017HH0096）

肿瘤预防与治疗

OACSTPCD

1674-0904

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