肿瘤预防与治疗2019，Vol.32Issue(1)：72-77,6.DOI:10. 3969／j. issn. 1674-0904. 2019. 01. 011
鼻咽癌适形调强放疗后长期幸存者认知功能和生活质量横断面调查
Cognitive Function and Quality of Life for Long-term Survivors of Naso-pharyngeal Cancer Treated by Intensity-modulated Radiation Therapy: A Cross-sectional Study
Zhang Xin 1Li Cong 1Shu Xiaolei 1Long Bin1
作者信息
- 1. Department of Radiotherapy, Chongqing University Cancer Hospital/Chongqing Cancer Institute/Chongqing Cancer Hospital, Chongqing 400030, China
- 折叠
摘要
Abstract
Objective: To study the cognitive function, quality of life (QOL) and moods of long-term survivors of naso-pharyngeal cancer (NPC) patients treated by intensity-modulated radiotherapy (IMRT). Methods: A cross-sectional study evaluating 54 NPC survivors with IMRT in our hospital was conducted. We used Montreal Cognitive Assessment (MoCA) to test the cognitive function, used FACT-NP to test QOL, and used the Hospital Anxiety and Depression Scale (HADS) to test mood. Results: Median survival time after IMRT was 14. 5 months (7 months~6. 5 years), and the median age was 44. 5 years (18~71 years). In total, 34 patients(63. 0% )were defined as mild cognitive impairment. Higher MoCA scores were associated with higher education level. Bilateral temporal lobe with Dmax ≥65 Gy or V60≥1. 10 cm3 was a risk factor for cognitive impairment. Age, gender, smoking and alcohol history, complicated diseases, mood scores, TNM stage, chemo-therapy, time after IMRT, QOL did not correlate with MoCA scores. One patient (1. 9% ) suffered from anxiety and 4 (7. 4% ) suffered from depression. The higher the depression score was, the lower the QOL score was. Conclusion: Mild cognitive impairment after IMRT is common in NPC survivors. Education level and radiation dose of temporal lobe were asso- ciated with cognitive function. Anxiety and depression are not common but will affect the QQL.关键词
鼻咽癌/适形调强放疗/认知功能/生活质量Key words
Nasopharyngeal cancer/ Intensity-modulated radiotherapy/ Cognitive function/ Quality of life分类
医药卫生引用本文复制引用
Zhang Xin,Li Cong,Shu Xiaolei,Long Bin..鼻咽癌适形调强放疗后长期幸存者认知功能和生活质量横断面调查[J].肿瘤预防与治疗,2019,32(1):72-77,6.
