肿瘤预防与治疗2019，Vol.32Issue(2)：103-113,11.DOI:10. 3969／j. issn. 1674-0904. 2019. 02. 002
中国大陆女性体检人群中人乳头瘤病毒型别感染率及九价疫苗中HPV各型别分布的系统评价
Genotype-specific Prevalence and Distribution of Cervical Human Papillo-mavirus in Women Undergoing Health Check-ups in Mainland China: a Systematic Review Based on Population-Based Studies
摘要
Abstract
Objective: We aimed to assess the genotype-specific prevalence and distribution of cervical human papilloma-virus (HPV) in women undergoing health check-ups in mainland China by systematic reviews, in order to provide scientific evidence for promoting HPV 9-valent vaccine. Methods: Population-based studies on HPV prevalence published between Jan 1995 and Dec 2016 were retrieved from Pubmed, Medline and Chinese databases (CNKI, VIP and Wanfang). Detailed information like populations, cytological or pathological diagnosis, methods for HPV DNA detection and type was collected. In total, 19 studies were left for final evaluation using Stata 12. 0. Results: The overall prevalence of HPV infection among 83,561 women in mainland China was 16. 18% (95% CI: 14. 16, 18. 20). The prevalence of high-risk type and low-risk type HPV was 12. 95% and 3. 82% , respectively. The prevalence of high-risk type, low-risk type and all-type HPV covered by 9-valent vaccine was 10. 59% , 1. 56% , and 12. 15% [95% CI (10. 18, 14. 13)% ]. The most common HPV types were HPV-16, HPV-52, HPV-58, HPV-33, HPV-18 and HPV-68. The genotype-specific prevalence of HPV varied in sev-en regions. The prevalence of all-type, high-risk type and low-risk type HPV in East China were 17. 54% [95% CI (16. 82, 18. 27)% ], 14. 17% [95% CI (13. 50, 14. 83)% ] and 3. 75% [95% CI (2. 11, 6. 11)% ], respectively; the Northwest reported the lowest prevalence of HPV [8. 79% , 95% CI (7. 47, 10. 26)% ], while the Southwest saw the lowest prevalence of high-risk and low-risk type HPV [3. 04% , 95% CI (2. 22, 4. 04)% vs 0. 14% , 95% CI (0. 02, 0. 49) % ]. The high-est prevalence of high-risk type HPV covered by 9-valent vaccine was seen in central China and East China [11. 36% , 95% CI (9. 33, 13. 40)% vs 11. 36% , 95% CI (10. 75, 11. 97)% ], while the lowest prevalence of that was in the northeast [7. 83% , 95% CI (7. 18, 8. 51)% ]. The highest and the lowest prevalence of low-risk type HPV covered by 9-valent vac-cine were in North China and central China [3. 50% , 95% CI (1. 93, 5. 80)% vs 0. 30% , 95% CI (0. 06, 0. 87)% ], re-spectively. The highest and lowest prevalence of all-type HPV covered by 9-valent vaccine were in North China and Northeast China [12. 75% , 95% CI (9. 64, 16. 42)% vs 8. 34% , 95% CI (7. 67, 9. 03)% ], respectively. The data were higher in southern China than those in northern China in the prevalence of overall, high-risk and low-risk HPV, and the difference was statistically significant. The prevalence of the low-risk HPV covered by 9-valent vaccine was higher in the northern China than that in the southern China. The genotype of low-risk HPV was different in northern and southern China. There was no statistically significant difference between northern and southern China in the prevalence of high-risk type and all-type HPV covered by 9-valent vaccine. In non-conditional Logistic regression analysis, the adjusted prevalence of HPV detected by GP5+／6+ primer system was significantly higher than that by other primer systems (P<0. 001); the total HPV infection rate increased as the publication year of included articles increased (P<0. 001). Conclusion: The incidence of HPV was relatively high among female health examinees in mainland China, and the most common types of HPV were HPV16, 52, 58, 33, 18 and 68. The genotype of HPV differs when the region varies. The highest incidence rate was observed in central China, while the lowest was observed in Northwest China. Therefore, the nine-valent HPV vaccine may be effective for health female examinees. The screening of cervical cancer, however, is still needed. More studies are expected to confirm the above conclusions.关键词
正常人群/HPV 型别/Meta 分析Key words
Healthy population/ HPV genotype/ Meta-analysis分类
医药卫生引用本文复制引用
Yu Yanqin,Fu Shilan,Xu Huifang,Wei Mengna,Chen Qi,Hu Shangying,Zhao Fanghui,Qiao Youlin..中国大陆女性体检人群中人乳头瘤病毒型别感染率及九价疫苗中HPV各型别分布的系统评价[J].肿瘤预防与治疗,2019,32(2):103-113,11.基金项目
中国医学科学院医学与健康科技创新工程(编号:2017-I2M-B&R-03 ),包头医学院基金项目(编号:BYJJ-YF 201723) （编号:2017-I2M-B&R-03 ）
