肿瘤预防与治疗2019，Vol.32Issue(2)：114-123,10.DOI:10. 3969／j. issn. 1674-0904. 2019. 02. 003
紫杉醇剂量密集化疗在原发性上皮性卵巢癌中疗效与安全性Meta分析
Efficacy and Safety of Paclitaxel Dose-dense Chemotherapy in Primary Epithelial Ovarian Cancer: a Meta-analysis
摘要
Abstract
Objective: To systematically evaluate the efficacy and safety of paclitaxel dose-dense chemotherapy in primary epithelial ovarian cancer. Methods: Conference-related abstracts and relevant articles were searched and manually retrieved from Cochrane Library, Pubmed, Embase, Medline, CINK, VIP, Wanfang, and CBM databases. We applied the Cochrane bias risk assessment tool (version 5. 1) to evaluate the risk of bias, and meta-analysis was conducted by RevMan 5. 3 software. Results: A total of 11 randomized control trials (4,590 patients) were included. Meta-analysis showed that there was no statistically significant difference between the ex-periment group and the control group in progression free survival (PFS) (HR=0. 89,95% CI 0. 77~1. 04,P=0. 14) and overall survival (OS) (HR=0. 94,95% CI 0. 82~1. 07,P=0. 35). Patient survival rate, objective response rate ( ORR) and disease control rate (DCR) were not improved (P>0. 05), while the incidence of progressive disease (PD) reduced (OR=0. 54 95% CI 0. 29~0. 99,P=0. 05). Subgroup analysis showed that dose-dense chemotherapy prolonged PFS in elderly patients (≥60 years) and FIGO stage III-IV patients (P<0. 05). Safety analysis showed that dose-dense chemo-therapy increased the incidence of anemia (OR=2. 35, 95% CI 1. 38~3. 99,P=0. 002) and diarrhea ( OR=1. 74,95% CI 1. 01~2. 74,P=0. 02) above grade 3. There were no statistically significant differences in other adverse reactions above grade 3 (P>0. 05). Conclusion: Dose-dense chemotherapy does not improve PFS, OS, ORR, DCR and survival rate in patients with primary epithelial ovarian cancer, and may increase incidence of anemia, diarrhea above grade 3. However, it may prolong PFS in elderly and advanced patients, and reduce the incidence of PD.关键词
原发性上皮性卵巢癌/紫杉醇/剂量密集/Meta分析/随机对照试验Key words
Primary epithelial ovarian cancer/ Paclitaxel/ Dose-dense/ Meta-analyses/ Randomized control trial分类
医药卫生引用本文复制引用
Ren Pingping,Wu Xiao,Li Jie,Zhao Xuxu,Zhang Ying,Wang Huiyan,Zhao Weidong..紫杉醇剂量密集化疗在原发性上皮性卵巢癌中疗效与安全性Meta分析[J].肿瘤预防与治疗,2019,32(2):114-123,10.基金项目
安徽省公益性研究联动计划项目(编号:1604f0804010) This study was supported by Commonweal Research Project of Anhui Province (NO. 1604f0804010). （编号:1604f0804010）
