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人乳头瘤病毒E6/E7 mRNA及p16/Ki-67蛋白共表达在不同级别宫颈病变中的临床意义

Guo Zhen Zhao Dongmei Jia Manman Guo Peipei Wu Zeni Chen Peipei Sun Xingyuan Zhang Sha-okai

肿瘤预防与治疗2019，Vol.32Issue(2)：124-129,6.

肿瘤预防与治疗2019，Vol.32Issue(2)：124-129,6.DOI:10. 3969／j. issn. 1674-0904. 2019. 02. 004

人乳头瘤病毒E6/E7 mRNA及p16/Ki-67蛋白共表达在不同级别宫颈病变中的临床意义

Co-expression of Human Papilloma Virus E6/E7 mRNA and p16/Ki-67 Protein in Different Phases of Cervical Lesions

Guo Zhen ¹Zhao Dongmei ²Jia Manman ³Guo Peipei ⁴Wu Zeni ⁵Chen Peipei ⁶Sun Xingyuan ⁶Zhang Sha-okai⁶

作者信息

1. Central Laboratory Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, Henan, China
2. Department of Pathology Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, Henan, China
3. Department of Gynecological Oncology Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, Henan, China
4. Department of Reproductive Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450008, Henan, China
5. Department of Epidemiology, Nation Cancer Center/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100021, China
6. Department of Cancer Prevention and Control Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, Henan, China
折叠

摘要

Abstract

Objective: To explore the clinical significance of human papillomavirus ( HPV) E6／E7 mRNA and p16／Ki-67 protein in different phases of cervical lesions. Methods: A total of 537 women were enrolled in the Second Affiliated Hos-pital of Zhengzhou University. E6／E7 mRNA and p16／Ki-67 were detected by APTIMA HPV assay and CINtec PLUS tech-nology, respectively. All admitted women underwent colposcopy biopsy and pathological examination. Results: The mean age of 537 women was 43. 88 ± 10. 97. The positive rates of HPV mRNA and p16／Ki-67 increased as pathologic diagnosis progressed (P<0. 001). For normal people, the positive rates of HPV mRNA and p16／Ki-67 were 19. 1% and 13. 1% , re-spectively. As for those with squamous cell carcinoma (SCC) of the cervix, the positive rates were 100. 0% and 97. 7% , re-spectively. The positive rates of HPV mRNA and p16／Ki-67 also increased as cytological results worsened ( P<0. 001). The positive rates of HPV mRNA and p16／Ki-67 were 18. 6% and 14. 2% in the normal group, and those in the SCC of the cervix group were 100% and 93. 5% , respectively. Conclusion: The expression of HPV mRNA and p16／Ki-67 protein are positively correlated with cervical lesions. The condition of cervical lesions can be effectively assessed by monitoring the ex-pression level of HPV mRNA and p16／Ki-67 protein.

关键词

人乳头瘤病毒/E6／E7 mRNA/p16／Ki-67/宫颈病变

Key words

Human papilloma virus/ E6／E7 mRNA/ p16／Ki-67/ Cervical lesions

分类

医药卫生

引用本文复制引用

Guo Zhen,Zhao Dongmei,Jia Manman,Guo Peipei,Wu Zeni,Chen Peipei,Sun Xingyuan,Zhang Sha-okai..人乳头瘤病毒E6/E7 mRNA及p16/Ki-67蛋白共表达在不同级别宫颈病变中的临床意义[J].肿瘤预防与治疗,2019,32(2):124-129,6.

基金项目

国家自然科学基金(编号:81502475),河南省科技攻关计划项目(编号: 172102310067) （编号:81502475）

肿瘤预防与治疗

OACSTPCD

ISSN：1674-0904

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