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子宫肌瘤患者血清性激素水平的Meta分析

Zhang Ying Wu Xiao Li Jie Ren Pingping Zhao Xuxu Ge Li Wang Huiyan Zhao Weidong

肿瘤预防与治疗2019，Vol.32Issue(2)：130-138,9.

肿瘤预防与治疗2019，Vol.32Issue(2)：130-138,9.DOI:10. 3969／j. issn. 1674-0904. 2019. 02. 005

子宫肌瘤患者血清性激素水平的Meta分析

A Meta Analysis of Serum Sex Hormone in Patients with Uterine Fibroids

Zhang Ying ¹Wu Xiao ¹Li Jie ¹Ren Pingping ¹Zhao Xuxu ¹Ge Li ²Wang Huiyan ³Zhao Weidong⁴

作者信息

1. Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, Anhui, China
2. Graduate School, Wannan Medical College, Wuhu 241000, Anhui, China
3. De-partment of Gynecological Oncology, Anhui Provincial Cancer Hospital, Hefei 230031, Anhui, China
4. Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, Anhui, China
折叠

摘要

Abstract

Objective: To systematically evaluate the differences in serum estrogen, progesterone, follicular stimulating hormone (FSH) and luteinizing hormone (LH) between patients with uterine fibroids and those without uterine fibroids, pro-viding a basis for risk assessment, clinical diagnosis and treatment of uterine fibroids. Methods: Relevant articles published in Pubmed, CNKI, Wanfang and VIP databases since 1995 were searched by computer. Quality of the selected articles was evaluated according to the Newcastle-Ottawa Scale. RevMan 5. 3 was used to draw forest plots, and Stata 12. 0 was used for influence analysis and publication bias evaluation. Results: Seventeen studies, comprising 1,549 cases of uterine fibroids and 863 cases in control group, were included. SMD and 95% CI were calculated. The results showed that serum FSH (SMD 0. 34, 95% CI:0. 10~0. 59,P=0. 006) and LH (SMD=0. 40, 95% CI: 0. 24~0. 55,P< 0. 001) in patients with uterine fibroids in follicular phase were higher than those in the control group, and that there were no statistically significant differ- ences between the two groups in serum estrogen and progesterone in follicular phase and serum estrogen, progesterone, FSH and LH in luteal phase. Conclusion:Women with higher serum FSH and LH during follicular phase risk higher incidence of uterine fibroids. The incidence of u- terine fibroids is not correlated to serum estrogen and progesterone in follicular phase and serum estrogen, progesterone, FSH and LH in luteal phase.

关键词

子宫肌瘤/性激素/雌激素/孕激素/卵泡刺激素/黄体生成素/Meta分析

Key words

Uterine fibroids/ Sex hormone/ Estrogen/ Progesterone/ Follicle stimulating hormone (FSH)/ Luteinizing hormone (LH)/ Meta-analysis

分类

医药卫生

引用本文复制引用

Zhang Ying,Wu Xiao,Li Jie,Ren Pingping,Zhao Xuxu,Ge Li,Wang Huiyan,Zhao Weidong..子宫肌瘤患者血清性激素水平的Meta分析[J].肿瘤预防与治疗,2019,32(2):130-138,9.

基金项目

安徽省公益性研究联动计划项目(编号:1604f0804010) This study was supported by Commonweal Research Project of Anhui Province (NO. 1604f0804010). （编号:1604f0804010）

肿瘤预防与治疗

OACSTPCD

ISSN：1674-0904

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