肿瘤预防与治疗2019，Vol.32Issue(2)：188-193,6.DOI:10. 3969／j. issn. 1674-0904. 2019. 02. 017
恶性肿瘤相关性脑梗死的临床特点及相关危险因素分析
Clinical Characteristics and Impact Factors of Cerebral Infarction Caused by Nonintracranial Malignant Tumor
Gong Qianqian 1Song Chunjiang 1Long Xiuying 1Zhong Xiaomin 1Liu Mei1
作者信息
- 1. Department of Neurology, The Sixth People’s Hospital of Chengdu, Chengdu 610031, Sichuan, China
- 折叠
摘要
Abstract
Objective: To investigate the clinical characteristics and impact factors of cerebral Infarction in patients with nonintracranial malignant tumor, as well as its possible mechanism. Methods: A 1∶2 matched case-control study design was applied and 62 cases of cerebral infarction caused by nonintracranial malignant tumor were collected as the intervention group, while 124 non-cancer patients with cerebral infarction (Group A), 124 cancer patients without cerebral infarction (Group B) and 124 healthy people (Group C) were collected and matched as control groups according to age, gender, ad-mission time and tumor type. Clinical data were compared among groups. Results: The proportion of risk factors of the inter-vention group was significantly higher than that in Group A (P<0. 05), but was not significantly different from that in Group B and Group C (P>0. 05). At the same time, most of the patients in the intervention group had head magnetic resonance imaging (MRI) manifestations of multiple lesions in two or more arterial blood supply areas. The dichotomous 1∶2 conditional logistic regression analysis showed that the level of D-dimer, the presence or absence of metastasis and the three APTT inde- pendent variables entered the regression equation. Then we combined with the parameter level and relative risk ( RR) of each variable, when other independent variables were fixed ( RR=1. 984,95% CI:1. 235~3. 258,P<0. 001). The incidence of metastases in Group B increased by 98. 4% . The risk of cerebral infarction was 1. 692-fold (RR=0. 692,95% CI:1. 456 ~2. 687,P<0. 001) for patients without metastases;the incidence of cerebral infarction was increased by 16. 1% for every 1-second reduction in APTT (RR=0. 839,95% CI:0. 769~0. 928,P<0. 001). Conclusion: Nonintracranial malignant tumor-related cerebral infarction is different from com-mon cerebral infarction. It does not have the risk factors of traditional cerebrovascular disease, and mainly focuses on multi-ple lesions. The hypercoagulable state of blood may be the underlying cause of cerebral infarction in patients with malignant tumor.关键词
恶性肿瘤/脑梗死/临床特点/危险因素Key words
Malignant tumor/ Cerebral infarction/ Clinical characteristic/ Risk factor分类
医药卫生引用本文复制引用
Gong Qianqian,Song Chunjiang,Long Xiuying,Zhong Xiaomin,Liu Mei..恶性肿瘤相关性脑梗死的临床特点及相关危险因素分析[J].肿瘤预防与治疗,2019,32(2):188-193,6.
