肿瘤预防与治疗2019，Vol.32Issue(3)：207-211,232,6.DOI:10. 3969／j. issn. 1674-0904. 2019. 03. 002
Xp11 . 2易位性肾癌的临床特点、治疗及预后*
Clinical Characteristics, Treatment and Prognosis of Xp11. 2 Transloca-tion Renal Cell Carcinoma
摘要
Abstract
Objective: To analyze the clinical features, treatment and prognosis of Xp11. 2 translocation renal cell carci-noma. Methods: Clinical data of 15 patients with Xp11. 2 translocation renal cell carcinoma diagnosed in the pathology de-partment of West China Hospital from January 2008 to June 2018 were retrospectively analyzed. In patients in stage I~III, nephron-sparing surgery was performed in 4 patients, and radical nephrectomy in 7 patients, and no adjuvant therapy was performed after operation. Of the 4 patients in stageⅣ, 2 underwent cytoreductive nephrectomy combined with targeted drug therapy, 1 underwent combined resection of primary and metastatic lesions, and 1 underwent optimal adjuvant therapy. The overall survival rate was analyzed by Kaplan-Meier analysis and single factor analysis was performed. The Log-rank test was used to compare the difference of survival rate between groups. Results: Of all the cases, there were 6 males and 9 females; the age was 5 to 60 years and the median age was 28 years; There were 5 cases under 18 years old and 13 cases less than 46 years old (86. 7% ). No recurrence or metastasis was found in patients in stage I~III during the follow-up. One of them had a second primary tumor during follow-up. Kap-lan-Meier analysis showed that the survival rate of patients in the T4／IV phase was lower than that of patients in the non-T4／IV phase, and the survival rate of patients with the tumor’s maximum diameter greater than 7cm was lower than that of pa-tients with the tumor’s maximum diameter smaller than 7cm. Conclusion: The incidence of Xp11. 2 translocation renal cell carcinoma is higher in females than in males. The clinical symptoms of Xp11. 2 translocation renal cell carcinoma are atypi-cal, and bone or lung metastasis is prone to occur in advanced patients. Surgery is the most important treatment for this dis-ease. Combined resection of primary and metastatic lesions can improve the survival time of advanced patients. The MSKCC score may be used as an indicator of prognosis in patients in stage IV. Tumor maximum diameter greater than 7cm and the T4／IV phase were probably potential prognostic factors.关键词
Xp11. 2易位/肾细胞癌/临床特点/预后Key words
Xp11. 2 translocation/ Renal cell carcinoma/ Clinical features/ Prognosis分类
医药卫生引用本文复制引用
Zhou Qi,Li Zhiping,Zhao Yaqin,Song Kun,Hu Qiancheng..Xp11 . 2易位性肾癌的临床特点、治疗及预后*[J].肿瘤预防与治疗,2019,32(3):207-211,232,6.基金项目
四川省科技厅科技基础研究(编号:2015JY0096) This study was supported by grants from Science & Technology Department of Sichuan Province ( NO. 2015JY0096) （编号:2015JY0096）
