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术前NLR、PLR在非小细胞肺癌患者预后中的价值*

Diao Peng Huang Qing Li Changlin Peng Qian Xie Tianpeng Tan Yan

肿瘤预防与治疗2019，Vol.32Issue(3)：212-220,9.

肿瘤预防与治疗2019，Vol.32Issue(3)：212-220,9.DOI:10. 3969／j. issn. 1674-0904. 2019. 03. 003

术前NLR、PLR在非小细胞肺癌患者预后中的价值*

Value of Preoperative NLR and PLR in the Prognosis of Non-small Cell Lung Cancer

Diao Peng ¹Huang Qing ²Li Changlin ²Peng Qian ¹Xie Tianpeng ³Tan Yan¹

作者信息

1. Department of Radiotherapy , Sichuan Cancer Hospital&Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, Sichuan, China
2. Department of Oncology, Chengdu First Peoples’ Hospital, Chengdu 610016, Sichuan, China
3. Department of Thoracic Surgery ,Sichuan Cancer Hospital&Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, Sichuan, China
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摘要

Abstract

Objective: To evaluate the value of preoperative neutrophil to lymphocyte ratio (NLR) and platelet to lym-phocyte ratio (PLR) in predicting the prognosis of patients with non-small cell lung cancer. Methods: The clinicopathologic data of 280 NSCLC patients undergoing radical surgery from January 2012 to April 2014 in Sichuan Cancer Hospital were ret-rospectively analyzed according to the receiver operating characteristic curve (ROC). The critical values of NLR and PLR were determined. The correlation between NLR and the prognosis of patients and that between PLR and the prognosis of pa-tients was analyzed, respectively. Results:NLR=3. 25 and PLR=122 were selected as the critical values. Univariate analy- sis showed that TNM staging, T staging, and N staging were related to disease-free survival (DFS), and the P values were 0. 001, 0. 007, and less than 0. 001; age, TNM staging, T staging, N staging, and PLR were associated with overall sur-vival ( OS), P values were 0. 006, < 0. 001, 0. 035, <0. 001, <0. 001, respectively. Multivariate analysis showed that TNM staging ( HR: 1. 627, 95% CI: 1. 030~2. 568, P=0. 037) was an independent risk factor affecting DFS. Age (HR: 1. 785, 95% CI: 1. 216~2. 622, P=0. 003), TNM stage (HR: 2. 094, 95% CI: 1. 231~3. 560, P=0. 006) and PLR (HR: 1. 833, 95% CI: 1. 257~2. 674, P=0. 002) were independent risk factor affecting OS. Conclusion: PLR may be used as an indicator to evaluate the prognosis of patients undergoing radical surgery for NSCLC.

关键词

非小细胞肺癌/中性粒细胞淋巴细胞比值/血小板淋巴细胞比值/预后

Key words

Non-small cell lung cancer/Neutrophil lymphocyte ratio/Platelet lymphocyte ratio/Prognosis

分类

医药卫生

引用本文复制引用

Diao Peng,Huang Qing,Li Changlin,Peng Qian,Xie Tianpeng,Tan Yan..术前NLR、PLR在非小细胞肺癌患者预后中的价值*[J].肿瘤预防与治疗,2019,32(3):212-220,9.

基金项目

四川省重点研发计划(编号:2017SZ0004) #共同第一作者 This study was supported by Sichuan Provincial Key Research and Development Program (NO. 2017SZ0004). （编号:2017SZ0004）

肿瘤预防与治疗

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ISSN：1674-0904

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