肿瘤预防与治疗2019，Vol.32Issue(3)：221-227,7.DOI:10. 3969／j. issn. 1674-0904. 2019. 03. 004
基于数据挖掘分析 NAMPT在脑胶质瘤中的表达及意义*
Expression of NAMPT and Its Prognostic Role in Glioma: Evidence Based on Data Mining
摘要
Abstract
Objective: To explore the expression of nicotinamide phosphoribosyltransferase( NAMPT) and the prognostic role it plays in glioma, and to perform Gene Ontology (GO) and Pathway annotation. Methods: The expression of NAMPT in several kinds of tumors were retrieved from the Oncomine database, and the prognostic data of NAMPT in glioma were re-trieved from Chinese Glioma Genome Atlas (CGGA) database and were analyzed. Biological processes, molecular functions, cellular component and related pathways were analyzed for NAMPT in glioma by GO and Pathway. Results: Totally, 426 studies on expression of NAMPT in different types of tumors were identified in the Oncomine database. The NAMPT expres- sion was significantly different in tumors of 43 studies, and were up-regulated in 24 (8 in glioma) and down-regulated in 19 studies ( none in glioma). NAMPT expression in glioma was higher than that in normal tissue (P<0. 05). Data from CGGA showed that glioblastoma patients with high expression of NAMPT tended to have a worse overall survival (P<0. 05); according to GO and Pathway annotation, NAMPT is in-volved in biological processes including NAD biosynthesis via nicotinamide riboside salvage pathway, cell-cell signaling, cir-cadian rhythm, cell proliferation, RNA polymerase II regulation, and signal transduction etc. Conclusion: NAMPT is highly expressed in glioma, and its expression is associated with the prognosis of glioblastoma, which may be a promising prognostic indicator for glioblastoma.关键词
胶质瘤/NAMPT/Oncomine/CGGAKey words
Glioma/ nicotinamide phosphoribosyltransferase/ Oncomine database/ Chinese Glioma Genome Atlas分类
医药卫生引用本文复制引用
Gou Xiaoxia,Ruan Peigang,Xu Ying,Wang Yanzhe,Xu Hui,Zeng Lingxiu,Zhang Guihai..基于数据挖掘分析 NAMPT在脑胶质瘤中的表达及意义*[J].肿瘤预防与治疗,2019,32(3):221-227,7.基金项目
遵义市汇川区科技局基金[遵汇科合(2017) 16号]、遵义医学院附属医院院级基金[院字(2011)10号] This study was supported by grants from the Science and Technology Bureau in Huichuan District of Zunyi (2017, No. 16) and grants from Affiliated Hospital of Zunyi Medical University (2011,No. 10). （2017）
