肿瘤预防与治疗2019，Vol.32Issue(3)：233-237,5.DOI:10. 3969／j. issn. 1674-0904. 2019. 03. 006
藏族人群甲状腺微小乳头状癌 BRAFV600E基因突变及临床意义*
BRAFV600E Mutation of Thyroid Micropapillary Microcarcinoma in the Tibetan Population and Its Clinical Significance
摘要
Abstract
[ Abstract] Objective: To analyze the relation between BRAFV600E mutation and the clinicopathological features of Tibetans with papillary thyroid microcarcinoma (PTMC). Methods: We performed a retrospective review of 69 PTMC patients who underwent surgical resection from May 2014 to May 2017 at our hospital. Clinical data were reviewed and BRAFV600E mutation were detected using quantitative fluorescence polymerase chain reaction. Results: Among Tibetans with PTMC, the inci-dence of BRAFV600E mutation was 60. 9 (42／69). Multifocal tumors were seen in 33. 3% (23／69) of cases. The incidence of extrathyroidal extension and lymph node metastasis were 30. 4% (21／69) and 23. 2% (16／69), respectively. Advanced-stage (defined as TNM III／IV) tumors was found in 21. 7% of the 69 patients. BRAFV600E mutation was associated with mul-tifocality (P=0. 036), extrathyroidal extension ( P =0. 024), lymph node metastasis ( P =0. 013) and advanced-stage tumors ( P = 0. 021 ). In addition to BRAFV600E mutation, there was a significantly positive correlation between lymph node metastasis and multifocality (P<0. 001) or extrathyroi-dal extension (P<0. 001). Conclusion: It is suggested that BRAFV600E mutation is relatively common among Tibetans with PTMC, and it is significantly associated with tumor multifocality, aggressiveness, metastases and clinical stages. The BRAFV600E mutation may be a useful prognostic molecular marker in identifying its progression and management of PTMC in appropriately defined clinical settings.关键词
甲状腺微小乳头状癌/BRAFV600E基因突变/临床病理特征Key words
Papillary thyroid microcarcinoma/BRAFV600E mutation/Clinicopathological features分类
医药卫生引用本文复制引用
He Dan,Zhu Ping,Liu Lin,Jiang Chenghao,Liu Yuze,Chen Zhenyong..藏族人群甲状腺微小乳头状癌 BRAFV600E基因突变及临床意义*[J].肿瘤预防与治疗,2019,32(3):233-237,5.基金项目
西藏成办分院院级科研项目(编号:2016-YJ-2). This study was supported by grants from Tibet Branch, West China Hospital, Sichuan University ( NO. 2016-YJ-2) （编号:2016-YJ-2）
